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Liquid Biopsy in Thyroid Cancer: New Insight

Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary...

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Detalles Bibliográficos
Autores principales: Khatami, Fatemeh, Tavangar, Seyed Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305265/
https://www.ncbi.nlm.nih.gov/pubmed/30595827
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author Khatami, Fatemeh
Tavangar, Seyed Mohammad
author_facet Khatami, Fatemeh
Tavangar, Seyed Mohammad
author_sort Khatami, Fatemeh
collection PubMed
description Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). The development of the noninvasive diagnostic tool for plasma genotyping, also known as “liquid biopsy”, brings a new insight for cancer diagnosis and prognosis. It is mainly containing circulating tumor DNA (ctDNA), circulating tumor cell (CTC), exosomes and extrachromosomal circular DNA (ecDNA). Liquid biopsy as a new plasma genotyping source brings a new prospective of tumor monitoring and therapy. It beneficially reduces the need of tissue biopsy and made early recognition of relapse as well. This article summarizes its components characteristics and their benefit in diagnosis and treatment of thyroid cancer.
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spelling pubmed-63052652018-12-28 Liquid Biopsy in Thyroid Cancer: New Insight Khatami, Fatemeh Tavangar, Seyed Mohammad Int J Hematol Oncol Stem Cell Res Review Article Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). The development of the noninvasive diagnostic tool for plasma genotyping, also known as “liquid biopsy”, brings a new insight for cancer diagnosis and prognosis. It is mainly containing circulating tumor DNA (ctDNA), circulating tumor cell (CTC), exosomes and extrachromosomal circular DNA (ecDNA). Liquid biopsy as a new plasma genotyping source brings a new prospective of tumor monitoring and therapy. It beneficially reduces the need of tissue biopsy and made early recognition of relapse as well. This article summarizes its components characteristics and their benefit in diagnosis and treatment of thyroid cancer. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018-07-01 /pmc/articles/PMC6305265/ /pubmed/30595827 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khatami, Fatemeh
Tavangar, Seyed Mohammad
Liquid Biopsy in Thyroid Cancer: New Insight
title Liquid Biopsy in Thyroid Cancer: New Insight
title_full Liquid Biopsy in Thyroid Cancer: New Insight
title_fullStr Liquid Biopsy in Thyroid Cancer: New Insight
title_full_unstemmed Liquid Biopsy in Thyroid Cancer: New Insight
title_short Liquid Biopsy in Thyroid Cancer: New Insight
title_sort liquid biopsy in thyroid cancer: new insight
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305265/
https://www.ncbi.nlm.nih.gov/pubmed/30595827
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