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The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity

The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum dis...

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Autores principales: d’Amora, Marta, Giordani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305331/
https://www.ncbi.nlm.nih.gov/pubmed/30618594
http://dx.doi.org/10.3389/fnins.2018.00976
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author d’Amora, Marta
Giordani, Silvia
author_facet d’Amora, Marta
Giordani, Silvia
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description The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum disorders as well as Alzheimer’s and Parkinson’s diseases. Zebrafish (Danio Rerio) have emerged as powerful toxicological model systems that can speed up chemical hazard assessment and can be used to extrapolate neurotoxic effects that chemicals have on humans. Zebrafish embryos and larvae are convenient for high-throughput screening of chemicals, due to their small size, low-cost, easy husbandry, and transparency. Additionally, zebrafish are homologous to other higher order vertebrates in terms of molecular signaling processes, genetic compositions, and tissue/organ structures as well as neurodevelopment. This mini review underlines the potential of the zebrafish as complementary models for developmental neurotoxicity screening of chemicals and describes the different endpoints utilized for such screening with some studies illustrating their use.
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spelling pubmed-63053312019-01-07 The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity d’Amora, Marta Giordani, Silvia Front Neurosci Neuroscience The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum disorders as well as Alzheimer’s and Parkinson’s diseases. Zebrafish (Danio Rerio) have emerged as powerful toxicological model systems that can speed up chemical hazard assessment and can be used to extrapolate neurotoxic effects that chemicals have on humans. Zebrafish embryos and larvae are convenient for high-throughput screening of chemicals, due to their small size, low-cost, easy husbandry, and transparency. Additionally, zebrafish are homologous to other higher order vertebrates in terms of molecular signaling processes, genetic compositions, and tissue/organ structures as well as neurodevelopment. This mini review underlines the potential of the zebrafish as complementary models for developmental neurotoxicity screening of chemicals and describes the different endpoints utilized for such screening with some studies illustrating their use. Frontiers Media S.A. 2018-12-18 /pmc/articles/PMC6305331/ /pubmed/30618594 http://dx.doi.org/10.3389/fnins.2018.00976 Text en Copyright © 2018 d’Amora and Giordani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
d’Amora, Marta
Giordani, Silvia
The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title_full The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title_fullStr The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title_full_unstemmed The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title_short The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
title_sort utility of zebrafish as a model for screening developmental neurotoxicity
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305331/
https://www.ncbi.nlm.nih.gov/pubmed/30618594
http://dx.doi.org/10.3389/fnins.2018.00976
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