Evaluating antimalarial efficacy by tracking glycolysis in Plasmodium falciparum using NMR spectroscopy

Glucose is an essential nutrient for Plasmodium falciparum and robust glycolytic activity is indicative of viable parasites. Using NMR spectroscopy, we show that P. falciparum infected erythrocytes consume ~20 times more glucose, and trophozoites metabolize ~6 times more glucose than ring stage para...

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Detalles Bibliográficos
Autores principales: Shivapurkar, Rupali, Hingamire, Tejashri, Kulkarni, Akshay S., Rajamohanan, P. R., Reddy, D. Srinivasa, Shanmugam, Dhanasekaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305384/
https://www.ncbi.nlm.nih.gov/pubmed/30584241
http://dx.doi.org/10.1038/s41598-018-36197-3

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