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Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response relies on two key proteins, LexA and RecA. Geneti...

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Detalles Bibliográficos
Autores principales:	Selwood, Trevor, Larsen, Brian J., Mo, Charlie Y., Culyba, Matthew J., Hostetler, Zachary M., Kohli, Rahul M., Reitz, Allen B., Baugh, Simon D. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305444/ https://www.ncbi.nlm.nih.gov/pubmed/30619111 http://dx.doi.org/10.3389/fmicb.2018.02961

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