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Sex Bias in Asthma Prevalence and Pathogenesis

Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including geneti...

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Detalles Bibliográficos
Autores principales: Shah, Ruchi, Newcomb, Dawn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305471/
https://www.ncbi.nlm.nih.gov/pubmed/30619350
http://dx.doi.org/10.3389/fimmu.2018.02997
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author Shah, Ruchi
Newcomb, Dawn C.
author_facet Shah, Ruchi
Newcomb, Dawn C.
author_sort Shah, Ruchi
collection PubMed
description Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, immunological responses, and sex hormones, affect the sex disparity associated with the development and control of asthma and other allergic diseases. Fluctuations of hormones during puberty, menstruation, pregnancy, and menopause, alter asthma symptoms and severity. In this article, we review clinical and epidemiological studies that examined the sex disparity in asthma and other allergic diseases as well as the role of sex hormones on asthma pathogenesis.
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spelling pubmed-63054712019-01-07 Sex Bias in Asthma Prevalence and Pathogenesis Shah, Ruchi Newcomb, Dawn C. Front Immunol Immunology Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, immunological responses, and sex hormones, affect the sex disparity associated with the development and control of asthma and other allergic diseases. Fluctuations of hormones during puberty, menstruation, pregnancy, and menopause, alter asthma symptoms and severity. In this article, we review clinical and epidemiological studies that examined the sex disparity in asthma and other allergic diseases as well as the role of sex hormones on asthma pathogenesis. Frontiers Media S.A. 2018-12-18 /pmc/articles/PMC6305471/ /pubmed/30619350 http://dx.doi.org/10.3389/fimmu.2018.02997 Text en Copyright © 2018 Shah and Newcomb. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shah, Ruchi
Newcomb, Dawn C.
Sex Bias in Asthma Prevalence and Pathogenesis
title Sex Bias in Asthma Prevalence and Pathogenesis
title_full Sex Bias in Asthma Prevalence and Pathogenesis
title_fullStr Sex Bias in Asthma Prevalence and Pathogenesis
title_full_unstemmed Sex Bias in Asthma Prevalence and Pathogenesis
title_short Sex Bias in Asthma Prevalence and Pathogenesis
title_sort sex bias in asthma prevalence and pathogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305471/
https://www.ncbi.nlm.nih.gov/pubmed/30619350
http://dx.doi.org/10.3389/fimmu.2018.02997
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