Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs

Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored t...

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Detalles Bibliográficos
Autores principales: SHIWA, Nozomi, NAKAJIMA, Chikage, KIMITSUKI, Kazunori, MANALO, Daria Llenaresas, NOGUCHI, Akira, INOUE, Satoshi, PARK, Chun-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305517/
https://www.ncbi.nlm.nih.gov/pubmed/30333382
http://dx.doi.org/10.1292/jvms.18-0519
Descripción
Sumario:Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.

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