Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy

To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomno...

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Autores principales: Hitomi, Takefumi, Inouchi, Morito, Takeyama, Hirofumi, Kobayashi, Katsuya, Sultana, Shamima, Inoue, Takeshi, Nakayama, Yuko, Shimotake, Akihiro, Matsuhashi, Masao, Matsumoto, Riki, Chin, Kazuo, Takahashi, Ryosuke, Ikeda, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305661/
https://www.ncbi.nlm.nih.gov/pubmed/30591883
http://dx.doi.org/10.1016/j.ebcr.2018.09.010
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author Hitomi, Takefumi
Inouchi, Morito
Takeyama, Hirofumi
Kobayashi, Katsuya
Sultana, Shamima
Inoue, Takeshi
Nakayama, Yuko
Shimotake, Akihiro
Matsuhashi, Masao
Matsumoto, Riki
Chin, Kazuo
Takahashi, Ryosuke
Ikeda, Akio
author_facet Hitomi, Takefumi
Inouchi, Morito
Takeyama, Hirofumi
Kobayashi, Katsuya
Sultana, Shamima
Inoue, Takeshi
Nakayama, Yuko
Shimotake, Akihiro
Matsuhashi, Masao
Matsumoto, Riki
Chin, Kazuo
Takahashi, Ryosuke
Ikeda, Akio
author_sort Hitomi, Takefumi
collection PubMed
description To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG) of 1 patient. Epileptiform discharges were significantly more frequent during the awake period (1.3 ± 1.2/min) than those during light sleep stages (0.02 ± 0.04/min) (P < 0.05). Regarding PSG analysis, epileptiform discharges were also reduced during all sleep stages compared to those during awake periods. Our study suggests a relative reduction in cortical irritability during sleep in BAFME.
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spelling pubmed-63056612018-12-27 Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy Hitomi, Takefumi Inouchi, Morito Takeyama, Hirofumi Kobayashi, Katsuya Sultana, Shamima Inoue, Takeshi Nakayama, Yuko Shimotake, Akihiro Matsuhashi, Masao Matsumoto, Riki Chin, Kazuo Takahashi, Ryosuke Ikeda, Akio Epilepsy Behav Case Rep Article To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG) of 1 patient. Epileptiform discharges were significantly more frequent during the awake period (1.3 ± 1.2/min) than those during light sleep stages (0.02 ± 0.04/min) (P < 0.05). Regarding PSG analysis, epileptiform discharges were also reduced during all sleep stages compared to those during awake periods. Our study suggests a relative reduction in cortical irritability during sleep in BAFME. Elsevier 2018-10-16 /pmc/articles/PMC6305661/ /pubmed/30591883 http://dx.doi.org/10.1016/j.ebcr.2018.09.010 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hitomi, Takefumi
Inouchi, Morito
Takeyama, Hirofumi
Kobayashi, Katsuya
Sultana, Shamima
Inoue, Takeshi
Nakayama, Yuko
Shimotake, Akihiro
Matsuhashi, Masao
Matsumoto, Riki
Chin, Kazuo
Takahashi, Ryosuke
Ikeda, Akio
Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title_full Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title_fullStr Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title_full_unstemmed Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title_short Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
title_sort sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305661/
https://www.ncbi.nlm.nih.gov/pubmed/30591883
http://dx.doi.org/10.1016/j.ebcr.2018.09.010
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