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Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression

We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a f...

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Detalles Bibliográficos
Autores principales:	Xu, Yi, Pang, Lizhi, Wang, Hongzhi, Xu, Congcong, Shah, Harshit, Guo, Peixuan, Shu, Dan, Qian, Steven Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305700/ https://www.ncbi.nlm.nih.gov/pubmed/30584980 http://dx.doi.org/10.1016/j.redox.2018.101085

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