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Reaction Mechanism and Substrate Specificity of Iso-orotate Decarboxylase: A Combined Theoretical and Experimental Study

The C-C bond cleavage catalyzed by metal-dependent iso-orotate decarboxylase (IDCase) from the thymidine salvage pathway is of interest for the elucidation of a (hypothetical) DNA demethylation pathway. IDCase appears also as a promising candidate for the synthetic regioselective carboxylation of N-...

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Detalles Bibliográficos
Autores principales:	Sheng, Xiang, Plasch, Katharina, Payer, Stefan E., Ertl, Claudia, Hofer, Gerhard, Keller, Walter, Braeuer, Simone, Goessler, Walter, Glueck, Silvia M., Himo, Fahmi, Faber, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305744/ https://www.ncbi.nlm.nih.gov/pubmed/30619817 http://dx.doi.org/10.3389/fchem.2018.00608

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