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Altered Expression of Mitochondrial NAD(+) Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism

Nicotinamide adenine dinucleotide (NAD(+)) represents an essential cofactor in sustaining cellular bioenergetics and maintaining cellular fitness, and has emerged as a therapeutic target to counteract aging and age-related diseases. Besides NAD(+) involvement in multiple redox reactions, it is also...

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Detalles Bibliográficos
Autores principales: Orlandi, Ivan, Stamerra, Giulia, Vai, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305841/
https://www.ncbi.nlm.nih.gov/pubmed/30619489
http://dx.doi.org/10.3389/fgene.2018.00676