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How does the promoter of an oocyte-specific gene function in male germ cells?

Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent...

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Autores principales: MIKI, Yuka, TSUKAMOTO, Satoshi, MINAMI, Naojiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305850/
https://www.ncbi.nlm.nih.gov/pubmed/30197401
http://dx.doi.org/10.1262/jrd.2018-060
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author MIKI, Yuka
TSUKAMOTO, Satoshi
MINAMI, Naojiro
author_facet MIKI, Yuka
TSUKAMOTO, Satoshi
MINAMI, Naojiro
author_sort MIKI, Yuka
collection PubMed
description Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex-specific gene expression.
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spelling pubmed-63058502019-01-03 How does the promoter of an oocyte-specific gene function in male germ cells? MIKI, Yuka TSUKAMOTO, Satoshi MINAMI, Naojiro J Reprod Dev Opinions and Hypotheses Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex-specific gene expression. The Society for Reproduction and Development 2018-09-10 2018-12 /pmc/articles/PMC6305850/ /pubmed/30197401 http://dx.doi.org/10.1262/jrd.2018-060 Text en ©2018 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Opinions and Hypotheses
MIKI, Yuka
TSUKAMOTO, Satoshi
MINAMI, Naojiro
How does the promoter of an oocyte-specific gene function in male germ cells?
title How does the promoter of an oocyte-specific gene function in male germ cells?
title_full How does the promoter of an oocyte-specific gene function in male germ cells?
title_fullStr How does the promoter of an oocyte-specific gene function in male germ cells?
title_full_unstemmed How does the promoter of an oocyte-specific gene function in male germ cells?
title_short How does the promoter of an oocyte-specific gene function in male germ cells?
title_sort how does the promoter of an oocyte-specific gene function in male germ cells?
topic Opinions and Hypotheses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305850/
https://www.ncbi.nlm.nih.gov/pubmed/30197401
http://dx.doi.org/10.1262/jrd.2018-060
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