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How does the promoter of an oocyte-specific gene function in male germ cells?
Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Society for Reproduction and Development
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305850/ https://www.ncbi.nlm.nih.gov/pubmed/30197401 http://dx.doi.org/10.1262/jrd.2018-060 |
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author | MIKI, Yuka TSUKAMOTO, Satoshi MINAMI, Naojiro |
author_facet | MIKI, Yuka TSUKAMOTO, Satoshi MINAMI, Naojiro |
author_sort | MIKI, Yuka |
collection | PubMed |
description | Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex-specific gene expression. |
format | Online Article Text |
id | pubmed-6305850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Society for Reproduction and Development |
record_format | MEDLINE/PubMed |
spelling | pubmed-63058502019-01-03 How does the promoter of an oocyte-specific gene function in male germ cells? MIKI, Yuka TSUKAMOTO, Satoshi MINAMI, Naojiro J Reprod Dev Opinions and Hypotheses Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex-specific gene expression. The Society for Reproduction and Development 2018-09-10 2018-12 /pmc/articles/PMC6305850/ /pubmed/30197401 http://dx.doi.org/10.1262/jrd.2018-060 Text en ©2018 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Opinions and Hypotheses MIKI, Yuka TSUKAMOTO, Satoshi MINAMI, Naojiro How does the promoter of an oocyte-specific gene function in male germ cells? |
title | How does the promoter of an oocyte-specific gene function in male germ cells? |
title_full | How does the promoter of an oocyte-specific gene function in male germ cells? |
title_fullStr | How does the promoter of an oocyte-specific gene function in male germ cells? |
title_full_unstemmed | How does the promoter of an oocyte-specific gene function in male germ cells? |
title_short | How does the promoter of an oocyte-specific gene function in male germ cells? |
title_sort | how does the promoter of an oocyte-specific gene function in male germ cells? |
topic | Opinions and Hypotheses |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305850/ https://www.ncbi.nlm.nih.gov/pubmed/30197401 http://dx.doi.org/10.1262/jrd.2018-060 |
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