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Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design

BACKGROUND: It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese ischemic stroke or transient ischemic attack (TIA) patients. Many vascular diseases can lead to ICAS, such as atherosclerosis, dissection, vasculitis, moyamoya disease, and reversible cerebral vasocons...

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Autores principales: Han, Yongjun, Qiao, Huiyu, Chen, Shuo, Jing, Jing, Pan, Yuesong, Li, Dongye, Liu, Yang, Meng, Xia, Wang, Yilong, Zhao, Xihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305940/
https://www.ncbi.nlm.nih.gov/pubmed/30456898
http://dx.doi.org/10.1002/brb3.1154
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author Han, Yongjun
Qiao, Huiyu
Chen, Shuo
Jing, Jing
Pan, Yuesong
Li, Dongye
Liu, Yang
Meng, Xia
Wang, Yilong
Zhao, Xihai
author_facet Han, Yongjun
Qiao, Huiyu
Chen, Shuo
Jing, Jing
Pan, Yuesong
Li, Dongye
Liu, Yang
Meng, Xia
Wang, Yilong
Zhao, Xihai
author_sort Han, Yongjun
collection PubMed
description BACKGROUND: It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese ischemic stroke or transient ischemic attack (TIA) patients. Many vascular diseases can lead to ICAS, such as atherosclerosis, dissection, vasculitis, moyamoya disease, and reversible cerebral vasoconstriction syndrome (RCVS). In addition, progression of intracranial atherosclerotic disease (ICAD) will increase the risk of ischemic cerebrovascular events. The ICASMAP study primarily aims to determine the etiology and disease distribution of ICAS using noninvasive magnetic resonance (MR) imaging and evaluate the rate for progression of ICAD in symptomatic population. METHODS: The ICASMAP study is a prospective, observational, and multicenter study by recruiting 300 subjects (18–80 years old) with recent stroke or TIA (within 2 weeks after onset of symptoms) in China. All the subjects will undergo MR imaging examination including brain and intracranial artery MR imaging at baseline. In addition, the clinical risk factors will be collected and blood biomarkers will be tested. A subgroup of more than 200 subjects who were diagnosed with ICAD according to baseline MR imaging will be followed up for 2 years. During the follow‐up study, MR imaging examination will be performed at 12 and 24 months. The primary end point is presence of progression of intracranial artery atherosclerotic plaques. CONCLUSIONS: The ICASMAP study investigates the etiology of ICAS and progression of ICAD in Chinese stroke patients and may help to improve the precise diagnosis and intervention of ICAS and stroke prevention.
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spelling pubmed-63059402019-01-02 Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design Han, Yongjun Qiao, Huiyu Chen, Shuo Jing, Jing Pan, Yuesong Li, Dongye Liu, Yang Meng, Xia Wang, Yilong Zhao, Xihai Brain Behav Methods BACKGROUND: It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese ischemic stroke or transient ischemic attack (TIA) patients. Many vascular diseases can lead to ICAS, such as atherosclerosis, dissection, vasculitis, moyamoya disease, and reversible cerebral vasoconstriction syndrome (RCVS). In addition, progression of intracranial atherosclerotic disease (ICAD) will increase the risk of ischemic cerebrovascular events. The ICASMAP study primarily aims to determine the etiology and disease distribution of ICAS using noninvasive magnetic resonance (MR) imaging and evaluate the rate for progression of ICAD in symptomatic population. METHODS: The ICASMAP study is a prospective, observational, and multicenter study by recruiting 300 subjects (18–80 years old) with recent stroke or TIA (within 2 weeks after onset of symptoms) in China. All the subjects will undergo MR imaging examination including brain and intracranial artery MR imaging at baseline. In addition, the clinical risk factors will be collected and blood biomarkers will be tested. A subgroup of more than 200 subjects who were diagnosed with ICAD according to baseline MR imaging will be followed up for 2 years. During the follow‐up study, MR imaging examination will be performed at 12 and 24 months. The primary end point is presence of progression of intracranial artery atherosclerotic plaques. CONCLUSIONS: The ICASMAP study investigates the etiology of ICAS and progression of ICAD in Chinese stroke patients and may help to improve the precise diagnosis and intervention of ICAS and stroke prevention. John Wiley and Sons Inc. 2018-11-19 /pmc/articles/PMC6305940/ /pubmed/30456898 http://dx.doi.org/10.1002/brb3.1154 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methods
Han, Yongjun
Qiao, Huiyu
Chen, Shuo
Jing, Jing
Pan, Yuesong
Li, Dongye
Liu, Yang
Meng, Xia
Wang, Yilong
Zhao, Xihai
Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title_full Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title_fullStr Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title_full_unstemmed Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title_short Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design
title_sort intracranial artery stenosis magnetic resonance imaging aetiology and progression study: rationale and design
topic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305940/
https://www.ncbi.nlm.nih.gov/pubmed/30456898
http://dx.doi.org/10.1002/brb3.1154
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