Subclinical Reactivation of Cytomegalovirus Drives CD4(+)CD28(null) T-Cell Expansion and Impaired Immune Response to Pneumococcal Vaccination in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

BACKGROUND: Infection is the leading cause of death in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Expansion of CD4(+)CD28(null) T cells is associated with increased risk of infection and mortality, but is only present in cytomegalovirus (CMV)–seropositive individuals. We hypoth...

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Detalles Bibliográficos
Autores principales: Chanouzas, Dimitrios, Sagmeister, Michael, Faustini, Sian, Nightingale, Peter, Richter, Alex, Ferro, Charles J, Morgan, Matthew David, Moss, Paul, Harper, Lorraine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306020/
https://www.ncbi.nlm.nih.gov/pubmed/30102389
http://dx.doi.org/10.1093/infdis/jiy493

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