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Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines
BACKGROUND: Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host’s susceptibility to subsequent ARIs. METHODS: A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 201...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306022/ https://www.ncbi.nlm.nih.gov/pubmed/30189092 http://dx.doi.org/10.1093/infdis/jiy515 |
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author | Furuse, Yuki Tamaki, Raita Okamoto, Michiko Saito-Obata, Mariko Suzuki, Akira Saito, Mayuko Imamura, Tadatsugu Khandaker, Irona Dapat, Isolde Ueno, Fumihiko Alday, Portia Parian Tan, Alvin Gue Inobaya, Marianette Tawat Segubre-Mercado, Edelwisa Tallo, Veronica Lupisan, Socorro Oshitani, Hitoshi |
author_facet | Furuse, Yuki Tamaki, Raita Okamoto, Michiko Saito-Obata, Mariko Suzuki, Akira Saito, Mayuko Imamura, Tadatsugu Khandaker, Irona Dapat, Isolde Ueno, Fumihiko Alday, Portia Parian Tan, Alvin Gue Inobaya, Marianette Tawat Segubre-Mercado, Edelwisa Tallo, Veronica Lupisan, Socorro Oshitani, Hitoshi |
author_sort | Furuse, Yuki |
collection | PubMed |
description | BACKGROUND: Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host’s susceptibility to subsequent ARIs. METHODS: A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. RESULTS: A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. CONCLUSIONS: This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host’s susceptibility to subsequent ARIs. |
format | Online Article Text |
id | pubmed-6306022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63060222019-01-07 Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines Furuse, Yuki Tamaki, Raita Okamoto, Michiko Saito-Obata, Mariko Suzuki, Akira Saito, Mayuko Imamura, Tadatsugu Khandaker, Irona Dapat, Isolde Ueno, Fumihiko Alday, Portia Parian Tan, Alvin Gue Inobaya, Marianette Tawat Segubre-Mercado, Edelwisa Tallo, Veronica Lupisan, Socorro Oshitani, Hitoshi J Infect Dis Major Articles and Brief Reports BACKGROUND: Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host’s susceptibility to subsequent ARIs. METHODS: A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. RESULTS: A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. CONCLUSIONS: This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host’s susceptibility to subsequent ARIs. Oxford University Press 2019-01-15 2018-09-05 /pmc/articles/PMC6306022/ /pubmed/30189092 http://dx.doi.org/10.1093/infdis/jiy515 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Articles and Brief Reports Furuse, Yuki Tamaki, Raita Okamoto, Michiko Saito-Obata, Mariko Suzuki, Akira Saito, Mayuko Imamura, Tadatsugu Khandaker, Irona Dapat, Isolde Ueno, Fumihiko Alday, Portia Parian Tan, Alvin Gue Inobaya, Marianette Tawat Segubre-Mercado, Edelwisa Tallo, Veronica Lupisan, Socorro Oshitani, Hitoshi Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title | Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title_full | Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title_fullStr | Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title_full_unstemmed | Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title_short | Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines |
title_sort | association between preceding viral respiratory infection and subsequent respiratory illnesses among children: a prospective cohort study in the philippines |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306022/ https://www.ncbi.nlm.nih.gov/pubmed/30189092 http://dx.doi.org/10.1093/infdis/jiy515 |
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