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Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease

Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacteria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by in...

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Autores principales: Suzuki, Anzu, Ito, Mikako, Hamaguchi, Tomonori, Mori, Hiroshi, Takeda, Yuka, Baba, Ryuko, Watanabe, Takeshi, Kurokawa, Ken, Asakawa, Susumu, Hirayama, Masaaki, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306167/
https://www.ncbi.nlm.nih.gov/pubmed/30586410
http://dx.doi.org/10.1371/journal.pone.0208313
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author Suzuki, Anzu
Ito, Mikako
Hamaguchi, Tomonori
Mori, Hiroshi
Takeda, Yuka
Baba, Ryuko
Watanabe, Takeshi
Kurokawa, Ken
Asakawa, Susumu
Hirayama, Masaaki
Ohno, Kinji
author_facet Suzuki, Anzu
Ito, Mikako
Hamaguchi, Tomonori
Mori, Hiroshi
Takeda, Yuka
Baba, Ryuko
Watanabe, Takeshi
Kurokawa, Ken
Asakawa, Susumu
Hirayama, Masaaki
Ohno, Kinji
author_sort Suzuki, Anzu
collection PubMed
description Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacteria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microbiota may be associated with the development and progression of PD. We measured the amount of hydrogen production using gas chromatography by seven bacterial strains, which represented seven major intestinal bacterial groups/genera/species. Blautia coccoides and Clostridium leptum produced the largest amount of hydrogen. Escherichia coli and Bacteroides fragilis constituted the second group that produced hydrogen 34- to 93-fold lower than B. coccoides. Bifidobacterium pseudocatenulatum and Atopobium parvulum constituted the third group that produced hydrogen 559- to 2164-fold lower than B. coccoides. Lactobacillus casei produced no detectable hydrogen. Assuming that taxonomically neighboring strains have similar hydrogen production, we simulated hydrogen production using intestinal microbiota that we previously reported, and found that PD patients produce a 2.2-fold lower amount of intestinal hydrogen compared to controls. The lower amount of intestinal hydrogen production in PD was also simulated in cohorts of two other countries. The number of hydrogen-producing intestinal bacteria may be associated with the development and progression of PD. Further studies are required to prove its beneficial effect.
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spelling pubmed-63061672019-01-08 Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease Suzuki, Anzu Ito, Mikako Hamaguchi, Tomonori Mori, Hiroshi Takeda, Yuka Baba, Ryuko Watanabe, Takeshi Kurokawa, Ken Asakawa, Susumu Hirayama, Masaaki Ohno, Kinji PLoS One Research Article Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacteria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microbiota may be associated with the development and progression of PD. We measured the amount of hydrogen production using gas chromatography by seven bacterial strains, which represented seven major intestinal bacterial groups/genera/species. Blautia coccoides and Clostridium leptum produced the largest amount of hydrogen. Escherichia coli and Bacteroides fragilis constituted the second group that produced hydrogen 34- to 93-fold lower than B. coccoides. Bifidobacterium pseudocatenulatum and Atopobium parvulum constituted the third group that produced hydrogen 559- to 2164-fold lower than B. coccoides. Lactobacillus casei produced no detectable hydrogen. Assuming that taxonomically neighboring strains have similar hydrogen production, we simulated hydrogen production using intestinal microbiota that we previously reported, and found that PD patients produce a 2.2-fold lower amount of intestinal hydrogen compared to controls. The lower amount of intestinal hydrogen production in PD was also simulated in cohorts of two other countries. The number of hydrogen-producing intestinal bacteria may be associated with the development and progression of PD. Further studies are required to prove its beneficial effect. Public Library of Science 2018-12-26 /pmc/articles/PMC6306167/ /pubmed/30586410 http://dx.doi.org/10.1371/journal.pone.0208313 Text en © 2018 Suzuki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Suzuki, Anzu
Ito, Mikako
Hamaguchi, Tomonori
Mori, Hiroshi
Takeda, Yuka
Baba, Ryuko
Watanabe, Takeshi
Kurokawa, Ken
Asakawa, Susumu
Hirayama, Masaaki
Ohno, Kinji
Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title_full Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title_fullStr Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title_full_unstemmed Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title_short Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
title_sort quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306167/
https://www.ncbi.nlm.nih.gov/pubmed/30586410
http://dx.doi.org/10.1371/journal.pone.0208313
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