Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a me...

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Detalles Bibliográficos
Autores principales: Kallimasioti-Pazi, Eirini M., Thelakkad Chathoth, Keerthi, Taylor, Gillian C., Meynert, Alison, Ballinger, Tracy, Kelder, Martijn J. E., Lalevée, Sébastien, Sanli, Ildem, Feil, Robert, Wood, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306241/
https://www.ncbi.nlm.nih.gov/pubmed/30540740
http://dx.doi.org/10.1371/journal.pbio.2005595

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