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Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study
BACKGROUND: Patients with atrial fibrillation are known to have a high risk of mortality. There is a paucity of population-based studies about the impact of atrial fibrillation on the mortality risk stratified by age, sex, and detailed causes of death. METHODS: A total of 15,411 patients with atrial...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306259/ https://www.ncbi.nlm.nih.gov/pubmed/30586468 http://dx.doi.org/10.1371/journal.pone.0209687 |
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author | Lee, Euijae Choi, Eue-Keun Han, Kyung-Do Lee, HyunJung Choe, Won-Seok Lee, So-Ryoung Cha, Myung-Jin Lim, Woo-Hyun Kim, Yong-Jin Oh, Seil |
author_facet | Lee, Euijae Choi, Eue-Keun Han, Kyung-Do Lee, HyunJung Choe, Won-Seok Lee, So-Ryoung Cha, Myung-Jin Lim, Woo-Hyun Kim, Yong-Jin Oh, Seil |
author_sort | Lee, Euijae |
collection | PubMed |
description | BACKGROUND: Patients with atrial fibrillation are known to have a high risk of mortality. There is a paucity of population-based studies about the impact of atrial fibrillation on the mortality risk stratified by age, sex, and detailed causes of death. METHODS: A total of 15,411 patients with atrial fibrillation from the Korean National Health Insurance Service-National Sample Cohort were enrolled, and causes of death were identified according to codes of the 10th revision of the International Classification of Diseases. RESULTS: From 2002 to 2013, a total of 4,479 (29%) deaths were confirmed, and the crude mortality rate for all-cause death was 63.3 per 1,000 patient-years. Patients with atrial fibrillation had a 3.7-fold increased risk of all-cause death compared with the general population. The standardized mortality ratio for all-cause death was the highest in young patients and decreased with increasing age (standardized mortality ratio 21.93, 95% confidence interval 7.60–26.26 in patients aged <20 years; standardized mortality ratio 2.77, 95% confidence interval 2.63–2.91 in patients aged ≥80 years). Women with atrial fibrillation exhibited a greater excess mortality risk than men (standardized mortality ratio 3.81, 95% confidence interval 3.65–3.98 in women; standardized mortality ratio 3.35, 95% confidence interval 3.21–3.48 in men). Cardiovascular disease was the leading cause of death (38.5%), and cerebral infarction was the most common specific disease. Patients with atrial fibrillation had an about 5 times increased risk of death due to cardiovascular disease compared with the general population. CONCLUSIONS: Patients with atrial fibrillation had a 4 times increased risk of mortality compared with the general population. However, the impact of atrial fibrillation on mortality decreased with age and in men. Cerebral infarction was the most common cause of death, and more attention should be paid to reducing the risk of stroke. |
format | Online Article Text |
id | pubmed-6306259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63062592019-01-08 Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study Lee, Euijae Choi, Eue-Keun Han, Kyung-Do Lee, HyunJung Choe, Won-Seok Lee, So-Ryoung Cha, Myung-Jin Lim, Woo-Hyun Kim, Yong-Jin Oh, Seil PLoS One Research Article BACKGROUND: Patients with atrial fibrillation are known to have a high risk of mortality. There is a paucity of population-based studies about the impact of atrial fibrillation on the mortality risk stratified by age, sex, and detailed causes of death. METHODS: A total of 15,411 patients with atrial fibrillation from the Korean National Health Insurance Service-National Sample Cohort were enrolled, and causes of death were identified according to codes of the 10th revision of the International Classification of Diseases. RESULTS: From 2002 to 2013, a total of 4,479 (29%) deaths were confirmed, and the crude mortality rate for all-cause death was 63.3 per 1,000 patient-years. Patients with atrial fibrillation had a 3.7-fold increased risk of all-cause death compared with the general population. The standardized mortality ratio for all-cause death was the highest in young patients and decreased with increasing age (standardized mortality ratio 21.93, 95% confidence interval 7.60–26.26 in patients aged <20 years; standardized mortality ratio 2.77, 95% confidence interval 2.63–2.91 in patients aged ≥80 years). Women with atrial fibrillation exhibited a greater excess mortality risk than men (standardized mortality ratio 3.81, 95% confidence interval 3.65–3.98 in women; standardized mortality ratio 3.35, 95% confidence interval 3.21–3.48 in men). Cardiovascular disease was the leading cause of death (38.5%), and cerebral infarction was the most common specific disease. Patients with atrial fibrillation had an about 5 times increased risk of death due to cardiovascular disease compared with the general population. CONCLUSIONS: Patients with atrial fibrillation had a 4 times increased risk of mortality compared with the general population. However, the impact of atrial fibrillation on mortality decreased with age and in men. Cerebral infarction was the most common cause of death, and more attention should be paid to reducing the risk of stroke. Public Library of Science 2018-12-26 /pmc/articles/PMC6306259/ /pubmed/30586468 http://dx.doi.org/10.1371/journal.pone.0209687 Text en © 2018 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Euijae Choi, Eue-Keun Han, Kyung-Do Lee, HyunJung Choe, Won-Seok Lee, So-Ryoung Cha, Myung-Jin Lim, Woo-Hyun Kim, Yong-Jin Oh, Seil Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title | Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title_full | Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title_fullStr | Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title_full_unstemmed | Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title_short | Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study |
title_sort | mortality and causes of death in patients with atrial fibrillation: a nationwide population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306259/ https://www.ncbi.nlm.nih.gov/pubmed/30586468 http://dx.doi.org/10.1371/journal.pone.0209687 |
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