Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium

BACKGROUND: We recently reported that myeloid sirtuin 6 (Sirt6) is a critical determinant of phenotypic switching and the migratory responses of macrophages. Given the prominent role of macrophages in the pathogenesis of rheumatoid arthritis (RA), we tested whether myeloid Sirt6 deficiency affects t...

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Detalles Bibliográficos
Autores principales: Woo, Seong Ji, Noh, Hae Sook, Lee, Na Young, Cheon, Yun-Hong, Yi, Sang Mi, Jeon, Hyun Min, Bae, Eun Ju, Lee, Sang-Il, Park, Byung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306347/
https://www.ncbi.nlm.nih.gov/pubmed/30429089
http://dx.doi.org/10.1016/j.ebiom.2018.11.005

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