Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act

Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to drivi...

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Detalles Bibliográficos
Autores principales: Kalia, Vandana, Sarkar, Surojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306427/
https://www.ncbi.nlm.nih.gov/pubmed/30619342
http://dx.doi.org/10.3389/fimmu.2018.02987
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author Kalia, Vandana
Sarkar, Surojit
author_facet Kalia, Vandana
Sarkar, Surojit
author_sort Kalia, Vandana
collection PubMed
description Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of IL-2 signals are considered in fine-tuning the balance of key transcriptional regulators of cell fate.
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spelling pubmed-63064272019-01-07 Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act Kalia, Vandana Sarkar, Surojit Front Immunol Immunology Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of IL-2 signals are considered in fine-tuning the balance of key transcriptional regulators of cell fate. Frontiers Media S.A. 2018-12-20 /pmc/articles/PMC6306427/ /pubmed/30619342 http://dx.doi.org/10.3389/fimmu.2018.02987 Text en Copyright © 2018 Kalia and Sarkar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kalia, Vandana
Sarkar, Surojit
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title_full Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title_fullStr Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title_full_unstemmed Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title_short Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
title_sort regulation of effector and memory cd8 t cell differentiation by il-2—a balancing act
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306427/
https://www.ncbi.nlm.nih.gov/pubmed/30619342
http://dx.doi.org/10.3389/fimmu.2018.02987
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AT sarkarsurojit regulationofeffectorandmemorycd8tcelldifferentiationbyil2abalancingact

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