Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

Atypical hemolytic uremic syndrome (aHUS) is a severe disease characterized by microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical hemolysis and organ failure, predominantly renal. Complement system overactivation is a hallmark of aHUS. To investigate this selective...

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Detalles Bibliográficos
Autores principales: May, Olivia, Merle, Nicolas S., Grunenwald, Anne, Gnemmi, Viviane, Leon, Juliette, Payet, Cloé, Robe-Rybkine, Tania, Paule, Romain, Delguste, Florian, Satchell, Simon C., Mathieson, Peter W., Hazzan, Marc, Boulanger, Eric, Dimitrov, Jordan D., Fremeaux-Bacchi, Veronique, Frimat, Marie, Roumenina, Lubka T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306430/
https://www.ncbi.nlm.nih.gov/pubmed/30619356
http://dx.doi.org/10.3389/fimmu.2018.03008

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