Cargando…

Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency

A 69-year-old Japanese man with a history of suprasellar surgery and irradiation developed bradykinesia and mild fatigue without muscle weakness, myalgia, pyramidal or extrapyramidal signs, parkinsonian symptoms, or ataxia. An endocrinological work-up revealed anterior hypopituitarism associated wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohara, Nobumasa, Hirokawa, Mayuko, Kobayashi, Michi, Ikeda, Yohei, Yoneoka, Yuichiro, Seki, Yasuhiro, Akiyama, Katsuhiko, Tani, Takashi, Terajima, Kenshi, Ozawa, Tetsutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306535/
https://www.ncbi.nlm.nih.gov/pubmed/30101905
http://dx.doi.org/10.2169/internalmedicine.1101-18
_version_ 1783382804554317824
author Ohara, Nobumasa
Hirokawa, Mayuko
Kobayashi, Michi
Ikeda, Yohei
Yoneoka, Yuichiro
Seki, Yasuhiro
Akiyama, Katsuhiko
Tani, Takashi
Terajima, Kenshi
Ozawa, Tetsutaro
author_facet Ohara, Nobumasa
Hirokawa, Mayuko
Kobayashi, Michi
Ikeda, Yohei
Yoneoka, Yuichiro
Seki, Yasuhiro
Akiyama, Katsuhiko
Tani, Takashi
Terajima, Kenshi
Ozawa, Tetsutaro
author_sort Ohara, Nobumasa
collection PubMed
description A 69-year-old Japanese man with a history of suprasellar surgery and irradiation developed bradykinesia and mild fatigue without muscle weakness, myalgia, pyramidal or extrapyramidal signs, parkinsonian symptoms, or ataxia. An endocrinological work-up revealed anterior hypopituitarism associated with secondary adrenal insufficiency. Higher brain function tests indicated an impaired frontal lobe function. The patient's bradykinesia, fatigue, and frontal lobe dysfunction improved within 2 weeks after the initiation of corticosteroid replacement therapy. To our knowledge, this is the first reported case of adrenal insufficiency manifesting as non-parkinsonian bradykinesia. Physicians should consider reversible non-parkinsonian bradykinesia associated with frontal lobe dysfunction as an unusual manifestation of adrenal insufficiency.
format Online
Article
Text
id pubmed-6306535
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-63065352018-12-27 Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency Ohara, Nobumasa Hirokawa, Mayuko Kobayashi, Michi Ikeda, Yohei Yoneoka, Yuichiro Seki, Yasuhiro Akiyama, Katsuhiko Tani, Takashi Terajima, Kenshi Ozawa, Tetsutaro Intern Med Case Report A 69-year-old Japanese man with a history of suprasellar surgery and irradiation developed bradykinesia and mild fatigue without muscle weakness, myalgia, pyramidal or extrapyramidal signs, parkinsonian symptoms, or ataxia. An endocrinological work-up revealed anterior hypopituitarism associated with secondary adrenal insufficiency. Higher brain function tests indicated an impaired frontal lobe function. The patient's bradykinesia, fatigue, and frontal lobe dysfunction improved within 2 weeks after the initiation of corticosteroid replacement therapy. To our knowledge, this is the first reported case of adrenal insufficiency manifesting as non-parkinsonian bradykinesia. Physicians should consider reversible non-parkinsonian bradykinesia associated with frontal lobe dysfunction as an unusual manifestation of adrenal insufficiency. The Japanese Society of Internal Medicine 2018-08-10 2018-12-01 /pmc/articles/PMC6306535/ /pubmed/30101905 http://dx.doi.org/10.2169/internalmedicine.1101-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ohara, Nobumasa
Hirokawa, Mayuko
Kobayashi, Michi
Ikeda, Yohei
Yoneoka, Yuichiro
Seki, Yasuhiro
Akiyama, Katsuhiko
Tani, Takashi
Terajima, Kenshi
Ozawa, Tetsutaro
Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title_full Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title_fullStr Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title_full_unstemmed Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title_short Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency
title_sort reversible non-parkinsonian bradykinesia with impaired frontal lobe function as the predominant manifestation of adrenal insufficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306535/
https://www.ncbi.nlm.nih.gov/pubmed/30101905
http://dx.doi.org/10.2169/internalmedicine.1101-18
work_keys_str_mv AT oharanobumasa reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT hirokawamayuko reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT kobayashimichi reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT ikedayohei reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT yoneokayuichiro reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT sekiyasuhiro reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT akiyamakatsuhiko reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT tanitakashi reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT terajimakenshi reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency
AT ozawatetsutaro reversiblenonparkinsonianbradykinesiawithimpairedfrontallobefunctionasthepredominantmanifestationofadrenalinsufficiency