Diazepam is not a direct allosteric modulator of α(1)‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

α(1A)‐ and α(1B)‐adrenoceptors (ARs) are G protein‐coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). α(1A)‐ and α(1B)‐AR are clinically targeted with antagonis...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, Lisa M., He, Xiaoji, Vaid, Tasneem M., Abdul‐Ridha, Alaa, Whitehead, Alice R., Gooley, Paul R., Bathgate, Ross A.D., Williams, Spencer J., Scott, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306559/
https://www.ncbi.nlm.nih.gov/pubmed/30619611
http://dx.doi.org/10.1002/prp2.455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306559/
https://www.ncbi.nlm.nih.gov/pubmed/30619611
http://dx.doi.org/10.1002/prp2.455

Ejemplares similares