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Diazepam is not a direct allosteric modulator of α(1)‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4
α(1A)‐ and α(1B)‐adrenoceptors (ARs) are G protein‐coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). α(1A)‐ and α(1B)‐AR are clinically targeted with antagonis...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306559/ https://www.ncbi.nlm.nih.gov/pubmed/30619611 http://dx.doi.org/10.1002/prp2.455 |