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Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease

Background: Kidney size is associated with renal function, however it is not elucidated whether kidney size is a risk for the progression of chronic kidney disease. The aim of this study was to investigate the predictive value of morphological evaluation of kidney size by ultrasonography for the pro...

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Autores principales: Hoi, Shotaro, Takata, Tomoaki, Sugihara, Takaaki, Ida, Ayami, Ogawa, Masaya, Mae, Yukari, Fukuda, Satoko, Munemura, Chishio, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306756/
https://www.ncbi.nlm.nih.gov/pubmed/30544567
http://dx.doi.org/10.3390/jcm7120527
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author Hoi, Shotaro
Takata, Tomoaki
Sugihara, Takaaki
Ida, Ayami
Ogawa, Masaya
Mae, Yukari
Fukuda, Satoko
Munemura, Chishio
Isomoto, Hajime
author_facet Hoi, Shotaro
Takata, Tomoaki
Sugihara, Takaaki
Ida, Ayami
Ogawa, Masaya
Mae, Yukari
Fukuda, Satoko
Munemura, Chishio
Isomoto, Hajime
author_sort Hoi, Shotaro
collection PubMed
description Background: Kidney size is associated with renal function, however it is not elucidated whether kidney size is a risk for the progression of chronic kidney disease. The aim of this study was to investigate the predictive value of morphological evaluation of kidney size by ultrasonography for the progression of renal dysfunction. Methods: Morphological parameters including kidney length, volume, cortical thickness, and medullary thickness were measured by ultrasonography in 87 patients with chronic kidney disease, and adjusted by body size. Renal functions at baseline and after 2 years were measured and the associations of morphological parameters to decline in renal function over 2 years were analyzed. Results: Height-adjusted cortical thickness was correlated to decline in renal function (r = 0.426, p < 0.001). Height-adjusted cortical thickness could predict renal dysfunction with the area under the curve of 0.786, and height-adjusted cortical thickness of 4.0 mm/cm was a cut off value with a sensitivity of 72.5% and a specificity of 80.0% for the risk of a more than 30% decline in renal function or initiation of dialysis. Conclusions: We provide new insights into the utility of measuring cortical thickness by ultrasonography for predict future renal impairment.
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spelling pubmed-63067562019-01-02 Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease Hoi, Shotaro Takata, Tomoaki Sugihara, Takaaki Ida, Ayami Ogawa, Masaya Mae, Yukari Fukuda, Satoko Munemura, Chishio Isomoto, Hajime J Clin Med Article Background: Kidney size is associated with renal function, however it is not elucidated whether kidney size is a risk for the progression of chronic kidney disease. The aim of this study was to investigate the predictive value of morphological evaluation of kidney size by ultrasonography for the progression of renal dysfunction. Methods: Morphological parameters including kidney length, volume, cortical thickness, and medullary thickness were measured by ultrasonography in 87 patients with chronic kidney disease, and adjusted by body size. Renal functions at baseline and after 2 years were measured and the associations of morphological parameters to decline in renal function over 2 years were analyzed. Results: Height-adjusted cortical thickness was correlated to decline in renal function (r = 0.426, p < 0.001). Height-adjusted cortical thickness could predict renal dysfunction with the area under the curve of 0.786, and height-adjusted cortical thickness of 4.0 mm/cm was a cut off value with a sensitivity of 72.5% and a specificity of 80.0% for the risk of a more than 30% decline in renal function or initiation of dialysis. Conclusions: We provide new insights into the utility of measuring cortical thickness by ultrasonography for predict future renal impairment. MDPI 2018-12-07 /pmc/articles/PMC6306756/ /pubmed/30544567 http://dx.doi.org/10.3390/jcm7120527 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hoi, Shotaro
Takata, Tomoaki
Sugihara, Takaaki
Ida, Ayami
Ogawa, Masaya
Mae, Yukari
Fukuda, Satoko
Munemura, Chishio
Isomoto, Hajime
Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title_full Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title_fullStr Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title_full_unstemmed Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title_short Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease
title_sort predictive value of cortical thickness measured by ultrasonography for renal impairment: a longitudinal study in chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306756/
https://www.ncbi.nlm.nih.gov/pubmed/30544567
http://dx.doi.org/10.3390/jcm7120527
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