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Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?

The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study’s objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of...

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Autores principales: Buss, Vera H., Lee, Kayla, Naunton, Mark, Peterson, Gregory M., Kosari, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306817/
https://www.ncbi.nlm.nih.gov/pubmed/30544669
http://dx.doi.org/10.3390/jcm7120533
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author Buss, Vera H.
Lee, Kayla
Naunton, Mark
Peterson, Gregory M.
Kosari, Sam
author_facet Buss, Vera H.
Lee, Kayla
Naunton, Mark
Peterson, Gregory M.
Kosari, Sam
author_sort Buss, Vera H.
collection PubMed
description The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study’s objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of medication misadventure and identify recommendations regarding the risk of QT interval prolongation made by pharmacists when performing medication reviews. In a retrospective evaluation, 500 medication review reports from Australian pharmacists were analysed. In patients taking at least one QT interval-prolonging drug, the individual risk of drug-induced QT interval prolongation was assessed. Recommendations of pharmacists to avoid the occurrence of this drug-related problem were examined. There was a high prevalence of use of potentially QT interval-prolonging drugs (71% patients), with 11% of patients taking at least one drug with a known risk. Pharmacists provided specific recommendations in only eight out of 35 patients (23%) with a high-risk score and taking drugs with known risk of QT interval prolongation. Pharmacists’ recommendations, when present, were focused on drugs with known risk of QT interval prolongation, rather than patients’ additional risk factors. There is a need to improve knowledge and awareness of this topic among pharmacists performing medication reviews.
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spelling pubmed-63068172019-01-02 Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity? Buss, Vera H. Lee, Kayla Naunton, Mark Peterson, Gregory M. Kosari, Sam J Clin Med Article The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study’s objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of medication misadventure and identify recommendations regarding the risk of QT interval prolongation made by pharmacists when performing medication reviews. In a retrospective evaluation, 500 medication review reports from Australian pharmacists were analysed. In patients taking at least one QT interval-prolonging drug, the individual risk of drug-induced QT interval prolongation was assessed. Recommendations of pharmacists to avoid the occurrence of this drug-related problem were examined. There was a high prevalence of use of potentially QT interval-prolonging drugs (71% patients), with 11% of patients taking at least one drug with a known risk. Pharmacists provided specific recommendations in only eight out of 35 patients (23%) with a high-risk score and taking drugs with known risk of QT interval prolongation. Pharmacists’ recommendations, when present, were focused on drugs with known risk of QT interval prolongation, rather than patients’ additional risk factors. There is a need to improve knowledge and awareness of this topic among pharmacists performing medication reviews. MDPI 2018-12-10 /pmc/articles/PMC6306817/ /pubmed/30544669 http://dx.doi.org/10.3390/jcm7120533 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buss, Vera H.
Lee, Kayla
Naunton, Mark
Peterson, Gregory M.
Kosari, Sam
Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title_full Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title_fullStr Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title_full_unstemmed Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title_short Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
title_sort identification of patients at-risk of qt interval prolongation during medication reviews: a missed opportunity?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306817/
https://www.ncbi.nlm.nih.gov/pubmed/30544669
http://dx.doi.org/10.3390/jcm7120533
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