Cargando…
The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study
Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-inf...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306820/ https://www.ncbi.nlm.nih.gov/pubmed/30477195 http://dx.doi.org/10.3390/jcm7120473 |
_version_ | 1783382864687005696 |
---|---|
author | Jiménez-Sousa, María Ángeles Gómez-Moreno, Ana Zaida Pineda-Tenor, Daniel Brochado-Kith, Oscar Sánchez-Ruano, Juan José Artaza-Varasa, Tomas Gómez-Sanz, Alicia Fernández-Rodríguez, Amanda Resino, Salvador |
author_facet | Jiménez-Sousa, María Ángeles Gómez-Moreno, Ana Zaida Pineda-Tenor, Daniel Brochado-Kith, Oscar Sánchez-Ruano, Juan José Artaza-Varasa, Tomas Gómez-Sanz, Alicia Fernández-Rodríguez, Amanda Resino, Salvador |
author_sort | Jiménez-Sousa, María Ángeles |
collection | PubMed |
description | Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) in 208 patients who had liver stiffness measurement (LSM), which was assessed using transient elastography. No patient had cirrhosis at baseline (LSM ≥ 12.5 kPa). Results: At baseline, 53.8% were male, the median age was 47.1 years, 13.5% reported a high intake of alcohol, 10.1% were prior injection drug users, 85.3% were infected with HCV genotype 1, and 22.6% had previously failed antiviral therapy (pegylated-interferon-alpha/ribavirin). During a median follow-up of 46.6 months, 26 patients developed cirrhosis. The rs4374383 G carriers had a higher risk of increasing LSM (adjusted arithmetic mean ratio (aAMR) = 1.14; p = 0.006) and a higher likelihood of having an increase in LSM greater than 5 kPa (ΔLSM ≥ 5 kPa) (adjusted odds ratio (aOR) = 2.37; p = 0.029), and greater than 7 kPa (ΔLSM ≥ 7 kPa) (aOR = 3.24; p = 0.032), after controlling for confounding. The SNP’s association with cirrhosis progression was close to statistical significance (aOR = 2.18; p = 0.070). Conclusions: MERTK rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients. |
format | Online Article Text |
id | pubmed-6306820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63068202019-01-02 The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study Jiménez-Sousa, María Ángeles Gómez-Moreno, Ana Zaida Pineda-Tenor, Daniel Brochado-Kith, Oscar Sánchez-Ruano, Juan José Artaza-Varasa, Tomas Gómez-Sanz, Alicia Fernández-Rodríguez, Amanda Resino, Salvador J Clin Med Article Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) in 208 patients who had liver stiffness measurement (LSM), which was assessed using transient elastography. No patient had cirrhosis at baseline (LSM ≥ 12.5 kPa). Results: At baseline, 53.8% were male, the median age was 47.1 years, 13.5% reported a high intake of alcohol, 10.1% were prior injection drug users, 85.3% were infected with HCV genotype 1, and 22.6% had previously failed antiviral therapy (pegylated-interferon-alpha/ribavirin). During a median follow-up of 46.6 months, 26 patients developed cirrhosis. The rs4374383 G carriers had a higher risk of increasing LSM (adjusted arithmetic mean ratio (aAMR) = 1.14; p = 0.006) and a higher likelihood of having an increase in LSM greater than 5 kPa (ΔLSM ≥ 5 kPa) (adjusted odds ratio (aOR) = 2.37; p = 0.029), and greater than 7 kPa (ΔLSM ≥ 7 kPa) (aOR = 3.24; p = 0.032), after controlling for confounding. The SNP’s association with cirrhosis progression was close to statistical significance (aOR = 2.18; p = 0.070). Conclusions: MERTK rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients. MDPI 2018-11-23 /pmc/articles/PMC6306820/ /pubmed/30477195 http://dx.doi.org/10.3390/jcm7120473 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jiménez-Sousa, María Ángeles Gómez-Moreno, Ana Zaida Pineda-Tenor, Daniel Brochado-Kith, Oscar Sánchez-Ruano, Juan José Artaza-Varasa, Tomas Gómez-Sanz, Alicia Fernández-Rodríguez, Amanda Resino, Salvador The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title_full | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title_fullStr | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title_full_unstemmed | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title_short | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
title_sort | myeloid-epithelial-reproductive tyrosine kinase (mertk) rs4374383 polymorphism predicts progression of liver fibrosis in hepatitis c virus-infected patients: a longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306820/ https://www.ncbi.nlm.nih.gov/pubmed/30477195 http://dx.doi.org/10.3390/jcm7120473 |
work_keys_str_mv | AT jimenezsousamariaangeles themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT gomezmorenoanazaida themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT pinedatenordaniel themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT brochadokithoscar themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT sanchezruanojuanjose themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT artazavarasatomas themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT gomezsanzalicia themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT fernandezrodriguezamanda themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT resinosalvador themyeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT jimenezsousamariaangeles myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT gomezmorenoanazaida myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT pinedatenordaniel myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT brochadokithoscar myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT sanchezruanojuanjose myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT artazavarasatomas myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT gomezsanzalicia myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT fernandezrodriguezamanda myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy AT resinosalvador myeloidepithelialreproductivetyrosinekinasemertkrs4374383polymorphismpredictsprogressionofliverfibrosisinhepatitiscvirusinfectedpatientsalongitudinalstudy |