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Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306844/ https://www.ncbi.nlm.nih.gov/pubmed/30513782 http://dx.doi.org/10.3390/jcm7120504 |
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author | Barone, Michele Viggiani, Maria Teresa Anelli, Maria Grazia Fanizzi, Rosalinda Lorusso, Orsola Lopalco, Giuseppe Cantarini, Luca Di Leo, Alfredo Lapadula, Giovanni Iannone, Florenzo |
author_facet | Barone, Michele Viggiani, Maria Teresa Anelli, Maria Grazia Fanizzi, Rosalinda Lorusso, Orsola Lopalco, Giuseppe Cantarini, Luca Di Leo, Alfredo Lapadula, Giovanni Iannone, Florenzo |
author_sort | Barone, Michele |
collection | PubMed |
description | The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia. The present study included 168 patients of both genders, aged 40–75 years. All patients underwent a nutritional evaluation, physical activity level assessment, rheumatologic evaluation, and an MMI and muscle strength assessment. The prevalence of sarcopenia was about 20% in all the three rheumatologic diseases, whereas presarcopenia was significantly different in RA, PsA and AS (p = 0.006). At multivariate analysis, only age ≥60 years and the presence of a disability were associated with a significantly increased risk of sarcopenia (p = 0.006 and p = 0.01, respectively), while a higher C-reactive protein did not reach statistical significance. Sarcopenia is similar in RA, PsA and AS, whereas presarcopenia significantly differs in these three diseases. Disease activity/inflammation and nutritional aspects do not influence sarcopenia, while age ≥60 years and the presence of a disability significantly increase the risk of sarcopenia. |
format | Online Article Text |
id | pubmed-6306844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63068442019-01-02 Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors Barone, Michele Viggiani, Maria Teresa Anelli, Maria Grazia Fanizzi, Rosalinda Lorusso, Orsola Lopalco, Giuseppe Cantarini, Luca Di Leo, Alfredo Lapadula, Giovanni Iannone, Florenzo J Clin Med Article The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia. The present study included 168 patients of both genders, aged 40–75 years. All patients underwent a nutritional evaluation, physical activity level assessment, rheumatologic evaluation, and an MMI and muscle strength assessment. The prevalence of sarcopenia was about 20% in all the three rheumatologic diseases, whereas presarcopenia was significantly different in RA, PsA and AS (p = 0.006). At multivariate analysis, only age ≥60 years and the presence of a disability were associated with a significantly increased risk of sarcopenia (p = 0.006 and p = 0.01, respectively), while a higher C-reactive protein did not reach statistical significance. Sarcopenia is similar in RA, PsA and AS, whereas presarcopenia significantly differs in these three diseases. Disease activity/inflammation and nutritional aspects do not influence sarcopenia, while age ≥60 years and the presence of a disability significantly increase the risk of sarcopenia. MDPI 2018-12-01 /pmc/articles/PMC6306844/ /pubmed/30513782 http://dx.doi.org/10.3390/jcm7120504 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barone, Michele Viggiani, Maria Teresa Anelli, Maria Grazia Fanizzi, Rosalinda Lorusso, Orsola Lopalco, Giuseppe Cantarini, Luca Di Leo, Alfredo Lapadula, Giovanni Iannone, Florenzo Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title | Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title_full | Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title_fullStr | Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title_full_unstemmed | Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title_short | Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors |
title_sort | sarcopenia in patients with rheumatic diseases: prevalence and associated risk factors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306844/ https://www.ncbi.nlm.nih.gov/pubmed/30513782 http://dx.doi.org/10.3390/jcm7120504 |
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