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Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors

The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in...

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Autores principales: Barone, Michele, Viggiani, Maria Teresa, Anelli, Maria Grazia, Fanizzi, Rosalinda, Lorusso, Orsola, Lopalco, Giuseppe, Cantarini, Luca, Di Leo, Alfredo, Lapadula, Giovanni, Iannone, Florenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306844/
https://www.ncbi.nlm.nih.gov/pubmed/30513782
http://dx.doi.org/10.3390/jcm7120504
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author Barone, Michele
Viggiani, Maria Teresa
Anelli, Maria Grazia
Fanizzi, Rosalinda
Lorusso, Orsola
Lopalco, Giuseppe
Cantarini, Luca
Di Leo, Alfredo
Lapadula, Giovanni
Iannone, Florenzo
author_facet Barone, Michele
Viggiani, Maria Teresa
Anelli, Maria Grazia
Fanizzi, Rosalinda
Lorusso, Orsola
Lopalco, Giuseppe
Cantarini, Luca
Di Leo, Alfredo
Lapadula, Giovanni
Iannone, Florenzo
author_sort Barone, Michele
collection PubMed
description The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia. The present study included 168 patients of both genders, aged 40–75 years. All patients underwent a nutritional evaluation, physical activity level assessment, rheumatologic evaluation, and an MMI and muscle strength assessment. The prevalence of sarcopenia was about 20% in all the three rheumatologic diseases, whereas presarcopenia was significantly different in RA, PsA and AS (p = 0.006). At multivariate analysis, only age ≥60 years and the presence of a disability were associated with a significantly increased risk of sarcopenia (p = 0.006 and p = 0.01, respectively), while a higher C-reactive protein did not reach statistical significance. Sarcopenia is similar in RA, PsA and AS, whereas presarcopenia significantly differs in these three diseases. Disease activity/inflammation and nutritional aspects do not influence sarcopenia, while age ≥60 years and the presence of a disability significantly increase the risk of sarcopenia.
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spelling pubmed-63068442019-01-02 Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors Barone, Michele Viggiani, Maria Teresa Anelli, Maria Grazia Fanizzi, Rosalinda Lorusso, Orsola Lopalco, Giuseppe Cantarini, Luca Di Leo, Alfredo Lapadula, Giovanni Iannone, Florenzo J Clin Med Article The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia. The present study included 168 patients of both genders, aged 40–75 years. All patients underwent a nutritional evaluation, physical activity level assessment, rheumatologic evaluation, and an MMI and muscle strength assessment. The prevalence of sarcopenia was about 20% in all the three rheumatologic diseases, whereas presarcopenia was significantly different in RA, PsA and AS (p = 0.006). At multivariate analysis, only age ≥60 years and the presence of a disability were associated with a significantly increased risk of sarcopenia (p = 0.006 and p = 0.01, respectively), while a higher C-reactive protein did not reach statistical significance. Sarcopenia is similar in RA, PsA and AS, whereas presarcopenia significantly differs in these three diseases. Disease activity/inflammation and nutritional aspects do not influence sarcopenia, while age ≥60 years and the presence of a disability significantly increase the risk of sarcopenia. MDPI 2018-12-01 /pmc/articles/PMC6306844/ /pubmed/30513782 http://dx.doi.org/10.3390/jcm7120504 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barone, Michele
Viggiani, Maria Teresa
Anelli, Maria Grazia
Fanizzi, Rosalinda
Lorusso, Orsola
Lopalco, Giuseppe
Cantarini, Luca
Di Leo, Alfredo
Lapadula, Giovanni
Iannone, Florenzo
Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title_full Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title_fullStr Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title_full_unstemmed Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title_short Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors
title_sort sarcopenia in patients with rheumatic diseases: prevalence and associated risk factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306844/
https://www.ncbi.nlm.nih.gov/pubmed/30513782
http://dx.doi.org/10.3390/jcm7120504
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