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Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease
The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patien...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306949/ https://www.ncbi.nlm.nih.gov/pubmed/30477110 http://dx.doi.org/10.3390/jcm7120471 |
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author | Van Herck, Maarten Spruit, Martijn A. Burtin, Chris Djamin, Remco Antons, Jeanine Goërtz, Yvonne M. J. Ebadi, Zjala Janssen, Daisy J. A. Vercoulen, Jan H. Peters, Jeannette B. Thong, Melissa S. Y. Otker, Jacqueline Coors, Arnold Sprangers, Mirjam A. G. Muris, Jean W. M. Wouters, Emiel F. M. van ’t Hul, Alex J. |
author_facet | Van Herck, Maarten Spruit, Martijn A. Burtin, Chris Djamin, Remco Antons, Jeanine Goërtz, Yvonne M. J. Ebadi, Zjala Janssen, Daisy J. A. Vercoulen, Jan H. Peters, Jeannette B. Thong, Melissa S. Y. Otker, Jacqueline Coors, Arnold Sprangers, Mirjam A. G. Muris, Jean W. M. Wouters, Emiel F. M. van ’t Hul, Alex J. |
author_sort | Van Herck, Maarten |
collection | PubMed |
description | The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This retrospective cross-sectional study of outpatients with asthma upon referral to a chest physician assessed fatigue (Checklist Individual Strength-Fatigue (CIS-Fatigue)), lung function (spirometry), asthma control (Asthma Control Questionnaire (ACQ)), dyspnea (Medical Research Council (MRC) scale), exercise capacity (six-minute walk test (6MWT)), and asthma-related Quality-of-Life (QoL), Asthma Quality of Life Questionnaire (AQLQ) during a comprehensive health-status assessment. In total, 733 asthmatic patients were eligible and analyzed (47.4 ± 16.3 years, 41.1% male). Severe fatigue (CIS-Fatigue ≥ 36 points) was detected in 62.6% of patients. Fatigue was not related to airflow limitation (FEV1, ρ = −0.083); was related moderately to ACQ (ρ = 0.455), AQLQ (ρ = −0.554), and MRC (ρ = 0.435; all p-values < 0.001); and was related weakly to 6MWT (ρ = −0.243, p < 0.001). In stepwise multiple regression analysis, 28.9% of variance in fatigue was explained by ACQ (21.0%), MRC (6.5%), and age (1.4%). As for AQLQ, 42.2% of variance was explained by fatigue (29.8%), MRC (8.6%), exacerbation rate (2.6%), and age (1.2%). Severe fatigue is highly prevalent in asthmatic patients; it is an important determinant of disease-specific QoL and a crucial yet ignored patient-related outcome in patients with asthma. |
format | Online Article Text |
id | pubmed-6306949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63069492019-01-02 Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease Van Herck, Maarten Spruit, Martijn A. Burtin, Chris Djamin, Remco Antons, Jeanine Goërtz, Yvonne M. J. Ebadi, Zjala Janssen, Daisy J. A. Vercoulen, Jan H. Peters, Jeannette B. Thong, Melissa S. Y. Otker, Jacqueline Coors, Arnold Sprangers, Mirjam A. G. Muris, Jean W. M. Wouters, Emiel F. M. van ’t Hul, Alex J. J Clin Med Article The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This retrospective cross-sectional study of outpatients with asthma upon referral to a chest physician assessed fatigue (Checklist Individual Strength-Fatigue (CIS-Fatigue)), lung function (spirometry), asthma control (Asthma Control Questionnaire (ACQ)), dyspnea (Medical Research Council (MRC) scale), exercise capacity (six-minute walk test (6MWT)), and asthma-related Quality-of-Life (QoL), Asthma Quality of Life Questionnaire (AQLQ) during a comprehensive health-status assessment. In total, 733 asthmatic patients were eligible and analyzed (47.4 ± 16.3 years, 41.1% male). Severe fatigue (CIS-Fatigue ≥ 36 points) was detected in 62.6% of patients. Fatigue was not related to airflow limitation (FEV1, ρ = −0.083); was related moderately to ACQ (ρ = 0.455), AQLQ (ρ = −0.554), and MRC (ρ = 0.435; all p-values < 0.001); and was related weakly to 6MWT (ρ = −0.243, p < 0.001). In stepwise multiple regression analysis, 28.9% of variance in fatigue was explained by ACQ (21.0%), MRC (6.5%), and age (1.4%). As for AQLQ, 42.2% of variance was explained by fatigue (29.8%), MRC (8.6%), exacerbation rate (2.6%), and age (1.2%). Severe fatigue is highly prevalent in asthmatic patients; it is an important determinant of disease-specific QoL and a crucial yet ignored patient-related outcome in patients with asthma. MDPI 2018-11-23 /pmc/articles/PMC6306949/ /pubmed/30477110 http://dx.doi.org/10.3390/jcm7120471 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Van Herck, Maarten Spruit, Martijn A. Burtin, Chris Djamin, Remco Antons, Jeanine Goërtz, Yvonne M. J. Ebadi, Zjala Janssen, Daisy J. A. Vercoulen, Jan H. Peters, Jeannette B. Thong, Melissa S. Y. Otker, Jacqueline Coors, Arnold Sprangers, Mirjam A. G. Muris, Jean W. M. Wouters, Emiel F. M. van ’t Hul, Alex J. Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title | Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title_full | Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title_fullStr | Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title_full_unstemmed | Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title_short | Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease |
title_sort | fatigue is highly prevalent in patients with asthma and contributes to the burden of disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306949/ https://www.ncbi.nlm.nih.gov/pubmed/30477110 http://dx.doi.org/10.3390/jcm7120471 |
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