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Biochemical markers as diagnostic/prognostic indicators for ischemic disease

OBJECTIVE: The use of a biomarker was extremely useful in clinical emergencies such as stroke to aid in triage and early management of cases. The diagnostic accuracy of laboratory biomarkers is run to approve the identification of easy, cheap and fast tests associated with cerebral ischemia and intr...

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Autores principales: Alkireidmi, MA, Al-Abbasi, FA, Mehanna, MG, Moselhy, Said S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306977/
https://www.ncbi.nlm.nih.gov/pubmed/30602955
http://dx.doi.org/10.4314/ahs.v18i2.13
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author Alkireidmi, MA
Al-Abbasi, FA
Mehanna, MG
Moselhy, Said S
author_facet Alkireidmi, MA
Al-Abbasi, FA
Mehanna, MG
Moselhy, Said S
author_sort Alkireidmi, MA
collection PubMed
description OBJECTIVE: The use of a biomarker was extremely useful in clinical emergencies such as stroke to aid in triage and early management of cases. The diagnostic accuracy of laboratory biomarkers is run to approve the identification of easy, cheap and fast tests associated with cerebral ischemia and intracranial hemorrhage. The present study was designed to screen serum enolase activity, activities of CK-BB, LDH and lipid profile in patients with ischemic or related diseases as good diagnostic/ prognostic indicator for ischemic diseases. METHODS: Sixty male subjects in the age range of (45 ±2years) were divided into four groups each with 15 participants: Group (I) normal . Group (II) patients recently diagnosed as ischemic disease; Group (III) hypertensive patients and Group (IV); diabetic patients enolase activity (p<0.001) and CK-BB (p<0.01) in ischemic and hypertensive patients compared with control and diabetic groups. LDH level was significantly elevated in ischemic, hypertensive and diabetic patients compared with controls (p<0.001). The cut -off value for serum enolase was 62.5 nmol/l showing 90% sensitivity and 93% specificity for differentiation of ischemic disease. Positive correlations were observed between serum enolase (r = 0.56), and CK-BB (r = 0.53). CONCLUSION: Serum enolase can be considered as a more sensitive and specific marker and used as a sensitive diagnostic or prognostic marker for ischemic related diseases.
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spelling pubmed-63069772019-01-02 Biochemical markers as diagnostic/prognostic indicators for ischemic disease Alkireidmi, MA Al-Abbasi, FA Mehanna, MG Moselhy, Said S Afr Health Sci Articles OBJECTIVE: The use of a biomarker was extremely useful in clinical emergencies such as stroke to aid in triage and early management of cases. The diagnostic accuracy of laboratory biomarkers is run to approve the identification of easy, cheap and fast tests associated with cerebral ischemia and intracranial hemorrhage. The present study was designed to screen serum enolase activity, activities of CK-BB, LDH and lipid profile in patients with ischemic or related diseases as good diagnostic/ prognostic indicator for ischemic diseases. METHODS: Sixty male subjects in the age range of (45 ±2years) were divided into four groups each with 15 participants: Group (I) normal . Group (II) patients recently diagnosed as ischemic disease; Group (III) hypertensive patients and Group (IV); diabetic patients enolase activity (p<0.001) and CK-BB (p<0.01) in ischemic and hypertensive patients compared with control and diabetic groups. LDH level was significantly elevated in ischemic, hypertensive and diabetic patients compared with controls (p<0.001). The cut -off value for serum enolase was 62.5 nmol/l showing 90% sensitivity and 93% specificity for differentiation of ischemic disease. Positive correlations were observed between serum enolase (r = 0.56), and CK-BB (r = 0.53). CONCLUSION: Serum enolase can be considered as a more sensitive and specific marker and used as a sensitive diagnostic or prognostic marker for ischemic related diseases. Makerere Medical School 2018-06 /pmc/articles/PMC6306977/ /pubmed/30602955 http://dx.doi.org/10.4314/ahs.v18i2.13 Text en © 2018 Alkireidmi et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Alkireidmi, MA
Al-Abbasi, FA
Mehanna, MG
Moselhy, Said S
Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title_full Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title_fullStr Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title_full_unstemmed Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title_short Biochemical markers as diagnostic/prognostic indicators for ischemic disease
title_sort biochemical markers as diagnostic/prognostic indicators for ischemic disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306977/
https://www.ncbi.nlm.nih.gov/pubmed/30602955
http://dx.doi.org/10.4314/ahs.v18i2.13
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