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Secondary hyperparathyroidism among Nigerians with chronic kidney disease
BACKROUND: Secondary hyperparathyroidism (SHPT) is a manifestation of chronic kidney disease mineral bone disorder (CKD-MBD). SHPT is common in patients with chronic kidney disease (CKD) and is associated with significant morbidity and mortality. METHODS: A cross- sectional descriptive study involvi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Makerere Medical School
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306980/ https://www.ncbi.nlm.nih.gov/pubmed/30602972 http://dx.doi.org/10.4314/ahs.v18i2.30 |
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author | Gimba, Zumnan M Abene, Esala E Agbaji, Oche O O Agaba, Emmanuel I |
author_facet | Gimba, Zumnan M Abene, Esala E Agbaji, Oche O O Agaba, Emmanuel I |
author_sort | Gimba, Zumnan M |
collection | PubMed |
description | BACKROUND: Secondary hyperparathyroidism (SHPT) is a manifestation of chronic kidney disease mineral bone disorder (CKD-MBD). SHPT is common in patients with chronic kidney disease (CKD) and is associated with significant morbidity and mortality. METHODS: A cross- sectional descriptive study involving 230 patients with CKD. RESULTS: The mean age of the study population was 44.17±15.24 years. The median intact parathyroid hormone and alkaline phosphatase levels were 96pg/ml (range 4–953pg/ml) and 88 iu/l (range 10–800 iu/l) respectively. The mean (with standard deviation) calcium, serum phosphate, calcium phosphate product and haemoglobin levels were 2.22±0.29mmol/l, 1.8±0.62mmol/l, 3.94±1.42mmol(2)/l(2) and 9.90±1.87g/dl respectively. Majority of patients had advanced CKD with 70.3% of patients in stage G5. The prevalence rates of SHPT, hypocalcaemia, hyperphosphataemia, elevated alkaline phosphatase and elevated calcium phosphate product were 55.2%, 34.8%, 66.1%, 42.2% and 25.2% respectively. Univariate analysis revealed that SHPT was associated with hypocalcaemia, hyperphosphataemia, elevated alkaline phosphatase, proteinuria, anaemia, hypertension, left ventricular hypertrophy and stage of kidney disease; being worse with advancing kidney disease. Independently associated with SHPT were hypocalcaemia (OR=4.84), hyperphosphataemia (OR=3.06), and elevated alkaline phosphatase (OR=2.04). CONCLUSION: The prevalence of SHPT in CKD is high, occurs early and is independently associated with hypocalcaemia, hyperphosphataemia and elevated alkaline phosphatase. The prevalence of SHPT also increases with worsening renal function. |
format | Online Article Text |
id | pubmed-6306980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-63069802019-01-02 Secondary hyperparathyroidism among Nigerians with chronic kidney disease Gimba, Zumnan M Abene, Esala E Agbaji, Oche O O Agaba, Emmanuel I Afr Health Sci Articles BACKROUND: Secondary hyperparathyroidism (SHPT) is a manifestation of chronic kidney disease mineral bone disorder (CKD-MBD). SHPT is common in patients with chronic kidney disease (CKD) and is associated with significant morbidity and mortality. METHODS: A cross- sectional descriptive study involving 230 patients with CKD. RESULTS: The mean age of the study population was 44.17±15.24 years. The median intact parathyroid hormone and alkaline phosphatase levels were 96pg/ml (range 4–953pg/ml) and 88 iu/l (range 10–800 iu/l) respectively. The mean (with standard deviation) calcium, serum phosphate, calcium phosphate product and haemoglobin levels were 2.22±0.29mmol/l, 1.8±0.62mmol/l, 3.94±1.42mmol(2)/l(2) and 9.90±1.87g/dl respectively. Majority of patients had advanced CKD with 70.3% of patients in stage G5. The prevalence rates of SHPT, hypocalcaemia, hyperphosphataemia, elevated alkaline phosphatase and elevated calcium phosphate product were 55.2%, 34.8%, 66.1%, 42.2% and 25.2% respectively. Univariate analysis revealed that SHPT was associated with hypocalcaemia, hyperphosphataemia, elevated alkaline phosphatase, proteinuria, anaemia, hypertension, left ventricular hypertrophy and stage of kidney disease; being worse with advancing kidney disease. Independently associated with SHPT were hypocalcaemia (OR=4.84), hyperphosphataemia (OR=3.06), and elevated alkaline phosphatase (OR=2.04). CONCLUSION: The prevalence of SHPT in CKD is high, occurs early and is independently associated with hypocalcaemia, hyperphosphataemia and elevated alkaline phosphatase. The prevalence of SHPT also increases with worsening renal function. Makerere Medical School 2018-06 /pmc/articles/PMC6306980/ /pubmed/30602972 http://dx.doi.org/10.4314/ahs.v18i2.30 Text en © 2018 Gimba et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Gimba, Zumnan M Abene, Esala E Agbaji, Oche O O Agaba, Emmanuel I Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title | Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title_full | Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title_fullStr | Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title_full_unstemmed | Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title_short | Secondary hyperparathyroidism among Nigerians with chronic kidney disease |
title_sort | secondary hyperparathyroidism among nigerians with chronic kidney disease |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306980/ https://www.ncbi.nlm.nih.gov/pubmed/30602972 http://dx.doi.org/10.4314/ahs.v18i2.30 |
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