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Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study
BACKGROUND: Parkinson’s disease impacts health-related quality of life (HRQoL), however no studies inquired on predictors of HRQoL changes after rehabilitation. This study assessed the relationship between mobility domain of HRQoL measured by Parkinson’s Disease Questionnaires-39 (PDQ-39) and clinic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307132/ https://www.ncbi.nlm.nih.gov/pubmed/30607261 http://dx.doi.org/10.1186/s40945-018-0051-2 |
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author | Bowman, Thomas Gervasoni, Elisa Parelli, Riccardo Jonsdottir, Johanna Ferrarin, Maurizio Cattaneo, Davide Carpinella, Ilaria |
author_facet | Bowman, Thomas Gervasoni, Elisa Parelli, Riccardo Jonsdottir, Johanna Ferrarin, Maurizio Cattaneo, Davide Carpinella, Ilaria |
author_sort | Bowman, Thomas |
collection | PubMed |
description | BACKGROUND: Parkinson’s disease impacts health-related quality of life (HRQoL), however no studies inquired on predictors of HRQoL changes after rehabilitation. This study assessed the relationship between mobility domain of HRQoL measured by Parkinson’s Disease Questionnaires-39 (PDQ-39) and clinical-demographic characteristics and developed a model predicting changes after rehabilitation. METHODS: Subjects with Parkinson’s disease underwent rehabilitation treatment and completed the following predictors: 10-m walking test (10MWT), Timed Up and Go (TUG), Berg Balance scale (BBS), Activities-specific Balance Confidence scales (ABC), Freezing of Gait (FOGQ) and PDQ-39. Two general linear models were calculated to predict the relationship between HRQoL at baseline and to predict HRQoL changes after rehabilitation. RESULTS: Forty-two subjects (age 74.9 ± 7.3 years, Hoehn&Yahr 2.8 ± 0.6) completed the baseline evaluation. The first model (multiple R(2) = 0.59, F = 5.86, P < 0.001) showed that ABC (B = − 0.51, CI = − 0.86 to 0.15, R(2) = 0.41, P = 0.005) and FOGQ (B = 2.38, CI = 1.03 to 3.73, R(2) = 0.07, P = 0.001) were statistically significant predictors of mobility aspect of HRQoL at baseline. Thirty seven subjects completed the rehabilitation sessions, data were entered in the second model (multiple R(2) = 0.40, F = 4.24, P < 0.004) showing that gender (B = − 5.12, CI = − 9.86 to − 0.39, R(2) = 0.23, P = 0.034), Hoehn&Yahr (B = 10.93, CI = + 3.27 to + 18.61, R(2) = 0.22, P = 0.006) and PDQ-39 mobility at baseline (B = − 0.38, CI = − 0.63 to − 0.14, R(2) = 0.55, P = 0.002) were statistically significant predictors of changes of the mobility aspect of HRQoL. CONCLUSIONS: Balance confidence and Freezing of Gait are associated with the mobility aspect of HRQoL. Changes in mobility domain of HRQoL (as assessed by PDQ-39) are likely to be greater in males, in people at higher stages of the disease and in people with more severe limitation in mobility domain of HRQoL (as assessed by PDQ-39) before rehabilitation. Results might be different when considering different outcomes or different measures for the same outcome (performance mobility test instead of self-report questionnaires). Further investigations are needed to better understand other components of HRQoL in addition to mobility. TRIAL REGISTRATION: NCT02713971 registered March 8, 2016. |
format | Online Article Text |
id | pubmed-6307132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63071322019-01-03 Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study Bowman, Thomas Gervasoni, Elisa Parelli, Riccardo Jonsdottir, Johanna Ferrarin, Maurizio Cattaneo, Davide Carpinella, Ilaria Arch Physiother Research Article BACKGROUND: Parkinson’s disease impacts health-related quality of life (HRQoL), however no studies inquired on predictors of HRQoL changes after rehabilitation. This study assessed the relationship between mobility domain of HRQoL measured by Parkinson’s Disease Questionnaires-39 (PDQ-39) and clinical-demographic characteristics and developed a model predicting changes after rehabilitation. METHODS: Subjects with Parkinson’s disease underwent rehabilitation treatment and completed the following predictors: 10-m walking test (10MWT), Timed Up and Go (TUG), Berg Balance scale (BBS), Activities-specific Balance Confidence scales (ABC), Freezing of Gait (FOGQ) and PDQ-39. Two general linear models were calculated to predict the relationship between HRQoL at baseline and to predict HRQoL changes after rehabilitation. RESULTS: Forty-two subjects (age 74.9 ± 7.3 years, Hoehn&Yahr 2.8 ± 0.6) completed the baseline evaluation. The first model (multiple R(2) = 0.59, F = 5.86, P < 0.001) showed that ABC (B = − 0.51, CI = − 0.86 to 0.15, R(2) = 0.41, P = 0.005) and FOGQ (B = 2.38, CI = 1.03 to 3.73, R(2) = 0.07, P = 0.001) were statistically significant predictors of mobility aspect of HRQoL at baseline. Thirty seven subjects completed the rehabilitation sessions, data were entered in the second model (multiple R(2) = 0.40, F = 4.24, P < 0.004) showing that gender (B = − 5.12, CI = − 9.86 to − 0.39, R(2) = 0.23, P = 0.034), Hoehn&Yahr (B = 10.93, CI = + 3.27 to + 18.61, R(2) = 0.22, P = 0.006) and PDQ-39 mobility at baseline (B = − 0.38, CI = − 0.63 to − 0.14, R(2) = 0.55, P = 0.002) were statistically significant predictors of changes of the mobility aspect of HRQoL. CONCLUSIONS: Balance confidence and Freezing of Gait are associated with the mobility aspect of HRQoL. Changes in mobility domain of HRQoL (as assessed by PDQ-39) are likely to be greater in males, in people at higher stages of the disease and in people with more severe limitation in mobility domain of HRQoL (as assessed by PDQ-39) before rehabilitation. Results might be different when considering different outcomes or different measures for the same outcome (performance mobility test instead of self-report questionnaires). Further investigations are needed to better understand other components of HRQoL in addition to mobility. TRIAL REGISTRATION: NCT02713971 registered March 8, 2016. BioMed Central 2018-12-27 /pmc/articles/PMC6307132/ /pubmed/30607261 http://dx.doi.org/10.1186/s40945-018-0051-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Bowman, Thomas Gervasoni, Elisa Parelli, Riccardo Jonsdottir, Johanna Ferrarin, Maurizio Cattaneo, Davide Carpinella, Ilaria Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title | Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title_full | Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title_fullStr | Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title_full_unstemmed | Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title_short | Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson’s disease: a pilot study |
title_sort | predictors of mobility domain of health-related quality of life after rehabilitation in parkinson’s disease: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307132/ https://www.ncbi.nlm.nih.gov/pubmed/30607261 http://dx.doi.org/10.1186/s40945-018-0051-2 |
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