RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

BACKGROUND: RNA secondary structures in the 5′-untranslated regions (5′-UTR) of mRNAs are key to the post-transcriptional regulation of gene expression. While it is evident that non-canonical Hoogsteen-paired G-quadruplex (rG4) structures somehow contribute to the regulation of translation initiatio...

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Detalles Bibliográficos
Autores principales: Murat, Pierre, Marsico, Giovanni, Herdy, Barbara, Ghanbarian, Avazeh, Portella, Guillem, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307142/
https://www.ncbi.nlm.nih.gov/pubmed/30591072
http://dx.doi.org/10.1186/s13059-018-1602-2

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