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Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases
BACKGROUND: Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307150/ https://www.ncbi.nlm.nih.gov/pubmed/30587150 http://dx.doi.org/10.1186/s12885-018-5217-5 |
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author | Zhao, Juan Hu, Chunxiu Wang, Cheng Yu, Wei Guo, Yinglu Shi, Minghan Shui, Yongjie Wei, Qichun |
author_facet | Zhao, Juan Hu, Chunxiu Wang, Cheng Yu, Wei Guo, Yinglu Shi, Minghan Shui, Yongjie Wei, Qichun |
author_sort | Zhao, Juan |
collection | PubMed |
description | BACKGROUND: Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its synchronous metastatic lesions in some cases. In this study, we analyzed ER expression concordance between breast cancer primary tumor and metastatic lesions. METHODS: Paraffin blocks of 100 primary breast invasive ductal carcinoma cases with axillary lymph node metastases were collected. Five tissue cores were punched out from individual primary breast cancer, and one tissue core from each lymph node metastases to assemble tissue microarrays for ER staining. Samples were then scored as 0, 1+, 2+, and 3+ according to the number and intensity of ER stained tumor cells. RESULTS: For cases with ER 3+ (strong expression) in all cores of primary lesions (n = 38), ER expression in metastatic lymph node was found in 94.7% of the patients. 91.0% of the metastatic lymph nodes were ER positive, and 84.3% of them to be 3+. Among the 46 cases of ER negative expression in all cores of primary lesions, 39 of them had all the metastatic nodes being ER negative, and ER negative nodes were seen in 95.7% of the metastases. As for 16 cases of ER inconsistent expression in primary lesions, 4 cases showed negative ER expression in all metastatic nodes, 2 cases displayed diffuse consistent ER 3+ expression, and 10 cases displayed variant ER expression. CONCLUSIONS: The findings suggest that ER expression concordance between breast cancer primary lesion and its matched metastatic lesions could be estimated by primary tumor ER expression pattern. |
format | Online Article Text |
id | pubmed-6307150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63071502019-01-02 Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases Zhao, Juan Hu, Chunxiu Wang, Cheng Yu, Wei Guo, Yinglu Shi, Minghan Shui, Yongjie Wei, Qichun BMC Cancer Research Article BACKGROUND: Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its synchronous metastatic lesions in some cases. In this study, we analyzed ER expression concordance between breast cancer primary tumor and metastatic lesions. METHODS: Paraffin blocks of 100 primary breast invasive ductal carcinoma cases with axillary lymph node metastases were collected. Five tissue cores were punched out from individual primary breast cancer, and one tissue core from each lymph node metastases to assemble tissue microarrays for ER staining. Samples were then scored as 0, 1+, 2+, and 3+ according to the number and intensity of ER stained tumor cells. RESULTS: For cases with ER 3+ (strong expression) in all cores of primary lesions (n = 38), ER expression in metastatic lymph node was found in 94.7% of the patients. 91.0% of the metastatic lymph nodes were ER positive, and 84.3% of them to be 3+. Among the 46 cases of ER negative expression in all cores of primary lesions, 39 of them had all the metastatic nodes being ER negative, and ER negative nodes were seen in 95.7% of the metastases. As for 16 cases of ER inconsistent expression in primary lesions, 4 cases showed negative ER expression in all metastatic nodes, 2 cases displayed diffuse consistent ER 3+ expression, and 10 cases displayed variant ER expression. CONCLUSIONS: The findings suggest that ER expression concordance between breast cancer primary lesion and its matched metastatic lesions could be estimated by primary tumor ER expression pattern. BioMed Central 2018-12-27 /pmc/articles/PMC6307150/ /pubmed/30587150 http://dx.doi.org/10.1186/s12885-018-5217-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhao, Juan Hu, Chunxiu Wang, Cheng Yu, Wei Guo, Yinglu Shi, Minghan Shui, Yongjie Wei, Qichun Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title_full | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title_fullStr | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title_full_unstemmed | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title_short | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
title_sort | breast cancer primary tumor er expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307150/ https://www.ncbi.nlm.nih.gov/pubmed/30587150 http://dx.doi.org/10.1186/s12885-018-5217-5 |
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