Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

BACKGROUND: Novel anti-schistosomal multi-stage drugs are needed because only a single drug, praziquantel, is available for the treatment of schistosomiasis and is poorly effective on larval and juvenile stages of the parasite. Schistosomes have a complex life-cycle and multiple developmental stages...

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Detalles Bibliográficos
Autores principales: Guidi, Alessandra, Saccoccia, Fulvio, Gennari, Nadia, Gimmelli, Roberto, Nizi, Emanuela, Lalli, Cristiana, Paonessa, Giacomo, Papoff, Giuliana, Bresciani, Alberto, Ruberti, Giovina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307185/
https://www.ncbi.nlm.nih.gov/pubmed/30587243
http://dx.doi.org/10.1186/s13071-018-3268-8

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