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The association between serum magnesium levels and community-acquired pneumonia 30-day mortality

BACKGROUND: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day morta...

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Autores principales: Nasser, Roni, Naffaa, Mohammad E., Mashiach, Tanya, Azzam, Zaher S., Braun, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307202/
https://www.ncbi.nlm.nih.gov/pubmed/30587164
http://dx.doi.org/10.1186/s12879-018-3627-2
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author Nasser, Roni
Naffaa, Mohammad E.
Mashiach, Tanya
Azzam, Zaher S.
Braun, Eyal
author_facet Nasser, Roni
Naffaa, Mohammad E.
Mashiach, Tanya
Azzam, Zaher S.
Braun, Eyal
author_sort Nasser, Roni
collection PubMed
description BACKGROUND: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. METHODS: Retrospective overview of patients hospitalized with CAP between January 1, 2010 and December 31, 2016. Participants were analyzed retrospectively in order to identify the risk factors for a primary endpoint of 30-day mortality. Normal levels of magnesium levels in our laboratory varies between 1.35 and 2.4 mg/dl. RESULTS: 3851 patients were included in our cohort. Age > 75 years, blood urea nitrogen (BUN) > 20 mg/dl, hypoalbuminemia, and abnormal levels of magnesium were all associated with increased risk of 30-day mortality. Normal magnesium levels were associated with the lowest mortality rate (14.7%). Notably, within the normal levels, high normal magnesium levels (2–2.4 mg/dl) were correlated with higher mortality rates (30.3%) as compared to levels that ranged between 1.35–2 mg/dl (12.9%). Hypomagnesemia and hypermagnesemia were both associated with excess of 30-day mortality, 18.4 and 50%, respectively. CONCLUSION: Hypomagnesemia and hypermagnesemia on admission were associated with an increased rate of 30-day mortality among adult patients hospitalized with CAP. Interestingly, magnesium levels within the upper normal limits were associated with higher mortality.
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spelling pubmed-63072022019-01-02 The association between serum magnesium levels and community-acquired pneumonia 30-day mortality Nasser, Roni Naffaa, Mohammad E. Mashiach, Tanya Azzam, Zaher S. Braun, Eyal BMC Infect Dis Research Article BACKGROUND: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. METHODS: Retrospective overview of patients hospitalized with CAP between January 1, 2010 and December 31, 2016. Participants were analyzed retrospectively in order to identify the risk factors for a primary endpoint of 30-day mortality. Normal levels of magnesium levels in our laboratory varies between 1.35 and 2.4 mg/dl. RESULTS: 3851 patients were included in our cohort. Age > 75 years, blood urea nitrogen (BUN) > 20 mg/dl, hypoalbuminemia, and abnormal levels of magnesium were all associated with increased risk of 30-day mortality. Normal magnesium levels were associated with the lowest mortality rate (14.7%). Notably, within the normal levels, high normal magnesium levels (2–2.4 mg/dl) were correlated with higher mortality rates (30.3%) as compared to levels that ranged between 1.35–2 mg/dl (12.9%). Hypomagnesemia and hypermagnesemia were both associated with excess of 30-day mortality, 18.4 and 50%, respectively. CONCLUSION: Hypomagnesemia and hypermagnesemia on admission were associated with an increased rate of 30-day mortality among adult patients hospitalized with CAP. Interestingly, magnesium levels within the upper normal limits were associated with higher mortality. BioMed Central 2018-12-27 /pmc/articles/PMC6307202/ /pubmed/30587164 http://dx.doi.org/10.1186/s12879-018-3627-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Nasser, Roni
Naffaa, Mohammad E.
Mashiach, Tanya
Azzam, Zaher S.
Braun, Eyal
The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title_full The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title_fullStr The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title_full_unstemmed The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title_short The association between serum magnesium levels and community-acquired pneumonia 30-day mortality
title_sort association between serum magnesium levels and community-acquired pneumonia 30-day mortality
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307202/
https://www.ncbi.nlm.nih.gov/pubmed/30587164
http://dx.doi.org/10.1186/s12879-018-3627-2
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