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Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay

BACKGROUND: Right ventricular (RV) dysfunction is a known risk factor for increased mortality in cardiac surgery. However, the association between RV performance and ICU morbidity is largely unknown. METHODS: We performed a single-centre, retrospective study including cardiac surgery patients equipp...

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Autores principales: Bootsma, Inge T., Scheeren, Thomas W. L., de Lange, Fellery, Haenen, Johannes, Boonstra, Piet W., Boerma, E. Christaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307315/
https://www.ncbi.nlm.nih.gov/pubmed/30607248
http://dx.doi.org/10.1186/s40560-018-0351-3
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author Bootsma, Inge T.
Scheeren, Thomas W. L.
de Lange, Fellery
Haenen, Johannes
Boonstra, Piet W.
Boerma, E. Christaan
author_facet Bootsma, Inge T.
Scheeren, Thomas W. L.
de Lange, Fellery
Haenen, Johannes
Boonstra, Piet W.
Boerma, E. Christaan
author_sort Bootsma, Inge T.
collection PubMed
description BACKGROUND: Right ventricular (RV) dysfunction is a known risk factor for increased mortality in cardiac surgery. However, the association between RV performance and ICU morbidity is largely unknown. METHODS: We performed a single-centre, retrospective study including cardiac surgery patients equipped with a pulmonary artery catheter, enabling continuous right ventricular ejection fraction (RVEF) measurements. Primary endpoint of our study was ICU morbidity (as determined by ICU length of stay, duration of mechanical ventilation, usage of inotropic drugs and fluids, and kidney dysfunction) in relation to RVEF. Patients were divided into three groups according to their RVEF; < 20%, 20–30%, and > 30%. RESULTS: We included 1109 patients. Patients with a RVEF < 20% had a significantly longer stay in ICU, a longer duration of mechanical ventilation, higher fluid balance, a higher incidence of inotropic drug usage, and more increase in postoperative creatinine levels in comparison to the other subgroups. In a multivariate analysis, RVEF was independently associated with increased ICU length of stay (OR 0.934 CI 0.908–0.961, p < 0.001), prolonged duration of mechanical ventilation (OR 0.969, CI 0.942–0.998, p = 0.033), usage of inotropic drugs (OR 0.944, CI 0.917–0.971, p < 0.001), and increase in creatinine (OR 0.962, CI 0.934–0.991, p = 0.011). CONCLUSIONS: A decreased RVEF is independently associated with a complicated ICU stay. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40560-018-0351-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-63073152019-01-03 Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay Bootsma, Inge T. Scheeren, Thomas W. L. de Lange, Fellery Haenen, Johannes Boonstra, Piet W. Boerma, E. Christaan J Intensive Care Research BACKGROUND: Right ventricular (RV) dysfunction is a known risk factor for increased mortality in cardiac surgery. However, the association between RV performance and ICU morbidity is largely unknown. METHODS: We performed a single-centre, retrospective study including cardiac surgery patients equipped with a pulmonary artery catheter, enabling continuous right ventricular ejection fraction (RVEF) measurements. Primary endpoint of our study was ICU morbidity (as determined by ICU length of stay, duration of mechanical ventilation, usage of inotropic drugs and fluids, and kidney dysfunction) in relation to RVEF. Patients were divided into three groups according to their RVEF; < 20%, 20–30%, and > 30%. RESULTS: We included 1109 patients. Patients with a RVEF < 20% had a significantly longer stay in ICU, a longer duration of mechanical ventilation, higher fluid balance, a higher incidence of inotropic drug usage, and more increase in postoperative creatinine levels in comparison to the other subgroups. In a multivariate analysis, RVEF was independently associated with increased ICU length of stay (OR 0.934 CI 0.908–0.961, p < 0.001), prolonged duration of mechanical ventilation (OR 0.969, CI 0.942–0.998, p = 0.033), usage of inotropic drugs (OR 0.944, CI 0.917–0.971, p < 0.001), and increase in creatinine (OR 0.962, CI 0.934–0.991, p = 0.011). CONCLUSIONS: A decreased RVEF is independently associated with a complicated ICU stay. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40560-018-0351-3) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-27 /pmc/articles/PMC6307315/ /pubmed/30607248 http://dx.doi.org/10.1186/s40560-018-0351-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Bootsma, Inge T.
Scheeren, Thomas W. L.
de Lange, Fellery
Haenen, Johannes
Boonstra, Piet W.
Boerma, E. Christaan
Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title_full Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title_fullStr Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title_full_unstemmed Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title_short Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay
title_sort impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated icu stay
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307315/
https://www.ncbi.nlm.nih.gov/pubmed/30607248
http://dx.doi.org/10.1186/s40560-018-0351-3
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