Cargando…

Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children

The present study aimed to assess the usefulness of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the diagnosis of ventilator-associated pneumonia (VAP) in paediatric patients with congenital heart disease (CHD) following cardiac surgery. The current prospective study enrolle...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Chunxiang, Zhu, Limin, Gong, Xiaolei, Xu, Zhuoming, Liu, Yujie, Zhang, Mingjie, Cao, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307413/
https://www.ncbi.nlm.nih.gov/pubmed/30651775
http://dx.doi.org/10.3892/etm.2018.6905
_version_ 1783382997590867968
author Li, Chunxiang
Zhu, Limin
Gong, Xiaolei
Xu, Zhuoming
Liu, Yujie
Zhang, Mingjie
Cao, Qing
author_facet Li, Chunxiang
Zhu, Limin
Gong, Xiaolei
Xu, Zhuoming
Liu, Yujie
Zhang, Mingjie
Cao, Qing
author_sort Li, Chunxiang
collection PubMed
description The present study aimed to assess the usefulness of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the diagnosis of ventilator-associated pneumonia (VAP) in paediatric patients with congenital heart disease (CHD) following cardiac surgery. The current prospective study enrolled 48 patients with congenital heart diseases who were suspected of having VAP; these patients were undergoing cardiac surgery between August 2016 and October 2017 in the Cardiac Intensive Care Unit of Shanghai Children's Medical Center (Shanghai, China). A total of 31 patients were diagnosed with VAP using a polymerase chain reaction (PCR) assay, while 17 patients without VAP were designated as the Non-VAP group. A bronchoscopy was performed and samples were collected for measurement on the day that VAP was diagnosed. The sTREM-1 levels were measured in bronchoalveolar lavage fluid (BALF) and exhaled ventilator condensate (EVC). BALF specimens were also sent to the microbiology laboratory for PCR assays and quantitative culturing. The positive detection rate of bacteria using the PCR assay and traditional culture was 64.6% (31/48) and 39.6% (19/48). sTREM-1 was significantly higher in the BALF (146.21 pg/ml vs. 118.06 pg/ml) and EVC (125.29 pg/ml vs. 120.48 pg/ml) of patients with VAP demonstrated compared with the patients without VAP. The findings suggest that the detection of sTREM-1 in BALF and EVC samples may be useful for the diagnosis of VAP following heart surgery in children.
format Online
Article
Text
id pubmed-6307413
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-63074132019-01-16 Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children Li, Chunxiang Zhu, Limin Gong, Xiaolei Xu, Zhuoming Liu, Yujie Zhang, Mingjie Cao, Qing Exp Ther Med Articles The present study aimed to assess the usefulness of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the diagnosis of ventilator-associated pneumonia (VAP) in paediatric patients with congenital heart disease (CHD) following cardiac surgery. The current prospective study enrolled 48 patients with congenital heart diseases who were suspected of having VAP; these patients were undergoing cardiac surgery between August 2016 and October 2017 in the Cardiac Intensive Care Unit of Shanghai Children's Medical Center (Shanghai, China). A total of 31 patients were diagnosed with VAP using a polymerase chain reaction (PCR) assay, while 17 patients without VAP were designated as the Non-VAP group. A bronchoscopy was performed and samples were collected for measurement on the day that VAP was diagnosed. The sTREM-1 levels were measured in bronchoalveolar lavage fluid (BALF) and exhaled ventilator condensate (EVC). BALF specimens were also sent to the microbiology laboratory for PCR assays and quantitative culturing. The positive detection rate of bacteria using the PCR assay and traditional culture was 64.6% (31/48) and 39.6% (19/48). sTREM-1 was significantly higher in the BALF (146.21 pg/ml vs. 118.06 pg/ml) and EVC (125.29 pg/ml vs. 120.48 pg/ml) of patients with VAP demonstrated compared with the patients without VAP. The findings suggest that the detection of sTREM-1 in BALF and EVC samples may be useful for the diagnosis of VAP following heart surgery in children. D.A. Spandidos 2019-01 2018-10-31 /pmc/articles/PMC6307413/ /pubmed/30651775 http://dx.doi.org/10.3892/etm.2018.6905 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Li, Chunxiang
Zhu, Limin
Gong, Xiaolei
Xu, Zhuoming
Liu, Yujie
Zhang, Mingjie
Cao, Qing
Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title_full Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title_fullStr Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title_full_unstemmed Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title_short Soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
title_sort soluble triggering receptor expressed on myeloid cells-1 as a useful biomarker for diagnosing ventilator-associated pneumonia after congenital cardiac surgery in children
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307413/
https://www.ncbi.nlm.nih.gov/pubmed/30651775
http://dx.doi.org/10.3892/etm.2018.6905
work_keys_str_mv AT lichunxiang solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT zhulimin solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT gongxiaolei solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT xuzhuoming solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT liuyujie solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT zhangmingjie solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren
AT caoqing solubletriggeringreceptorexpressedonmyeloidcells1asausefulbiomarkerfordiagnosingventilatorassociatedpneumoniaaftercongenitalcardiacsurgeryinchildren