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Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood

Diagnostic value of urinary retinol binding protein (RBP), albumin (ALB) and aquaporin-2 (AQP2) in neonatal hydronephrosis and their relationship with the expression of monocyte chemoattractant protein 1 (MCP-1) in the prenatal maternal peripheral blood was investigated. Forty-six child patients wit...

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Autores principales: Zhi, Ma, Zhang, Yanan, Liu, Lixia, Wang, Huizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307484/
https://www.ncbi.nlm.nih.gov/pubmed/30651806
http://dx.doi.org/10.3892/etm.2018.6913
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author Zhi, Ma
Zhang, Yanan
Liu, Lixia
Wang, Huizhi
author_facet Zhi, Ma
Zhang, Yanan
Liu, Lixia
Wang, Huizhi
author_sort Zhi, Ma
collection PubMed
description Diagnostic value of urinary retinol binding protein (RBP), albumin (ALB) and aquaporin-2 (AQP2) in neonatal hydronephrosis and their relationship with the expression of monocyte chemoattractant protein 1 (MCP-1) in the prenatal maternal peripheral blood was investigated. Forty-six child patients with hydronephrosis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from December 2016 to November 2017 were selected as the observation group and the control included 46 normal newborn infants. The urinary RBP, ALB, AQP2 and the expression of MCP-1 in the prenatal maternal peripheral blood in the two groups were compared. The diagnostic value of the combination of urinary RBP, ALB and AQP2 for the neonatal hydronephrosis was accessed through the area under curve (AUC). The changes of urinary RBP, ALB and AQP2 of child patients were observed and the correlations between RBP, ALB, AQP2 and MCP-1 were analyzed. The concentrations of RBP and ALB in the observation group were obviously increased compared to those in the control group. The AQP2 concentration in the observation group was lower than that in the control group. In the observation group, the MCP-1 level in the prenatal maternal blood was significantly higher than that in the control group (P<0.05). After treatment, the concentration of RBP and ALB in the child patients were significantly decreased and AQP2 concentration was increased compared with that before treatment (P<0.05). The AUC of the diagnosis combining with RBP, ALB and AQP2 was 0.913. RBP and ALB were positively correlated to MCP-1 in the prenatal maternal peripheral blood and there was a negative correlation between AQP2 and MCP-1 (P<0.05). In conclusion, urinary RBP, ALB and AQP2 can be regarded as markers for the diagnosis of the neonatal hydronephrosis and they are also closely related to the MCP-1 level in the prenatal maternal peripheral blood.
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spelling pubmed-63074842019-01-16 Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood Zhi, Ma Zhang, Yanan Liu, Lixia Wang, Huizhi Exp Ther Med Articles Diagnostic value of urinary retinol binding protein (RBP), albumin (ALB) and aquaporin-2 (AQP2) in neonatal hydronephrosis and their relationship with the expression of monocyte chemoattractant protein 1 (MCP-1) in the prenatal maternal peripheral blood was investigated. Forty-six child patients with hydronephrosis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from December 2016 to November 2017 were selected as the observation group and the control included 46 normal newborn infants. The urinary RBP, ALB, AQP2 and the expression of MCP-1 in the prenatal maternal peripheral blood in the two groups were compared. The diagnostic value of the combination of urinary RBP, ALB and AQP2 for the neonatal hydronephrosis was accessed through the area under curve (AUC). The changes of urinary RBP, ALB and AQP2 of child patients were observed and the correlations between RBP, ALB, AQP2 and MCP-1 were analyzed. The concentrations of RBP and ALB in the observation group were obviously increased compared to those in the control group. The AQP2 concentration in the observation group was lower than that in the control group. In the observation group, the MCP-1 level in the prenatal maternal blood was significantly higher than that in the control group (P<0.05). After treatment, the concentration of RBP and ALB in the child patients were significantly decreased and AQP2 concentration was increased compared with that before treatment (P<0.05). The AUC of the diagnosis combining with RBP, ALB and AQP2 was 0.913. RBP and ALB were positively correlated to MCP-1 in the prenatal maternal peripheral blood and there was a negative correlation between AQP2 and MCP-1 (P<0.05). In conclusion, urinary RBP, ALB and AQP2 can be regarded as markers for the diagnosis of the neonatal hydronephrosis and they are also closely related to the MCP-1 level in the prenatal maternal peripheral blood. D.A. Spandidos 2019-01 2018-11-01 /pmc/articles/PMC6307484/ /pubmed/30651806 http://dx.doi.org/10.3892/etm.2018.6913 Text en Copyright: © Zhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhi, Ma
Zhang, Yanan
Liu, Lixia
Wang, Huizhi
Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title_full Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title_fullStr Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title_full_unstemmed Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title_short Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood
title_sort diagnostic value of urinary rbp, alb and aqp2 in neonatal hydronephrosis and the relationship with expression of mcp-1 in the prenatal maternal peripheral blood
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307484/
https://www.ncbi.nlm.nih.gov/pubmed/30651806
http://dx.doi.org/10.3892/etm.2018.6913
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