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Engaging African ancestry participants in SLE clinical trials
SLE is a complex autoimmune disease with genetic and clinical differences between patients that appear to reside along ancestral lines. Over the last 20 years, a preponderance of evidence has shown that SLE is more common and severe in minority populations, particularly in African ancestry (AA) wome...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307590/ https://www.ncbi.nlm.nih.gov/pubmed/30613420 http://dx.doi.org/10.1136/lupus-2018-000297 |
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author | Anjorin, Aderike Lipsky, Peter |
author_facet | Anjorin, Aderike Lipsky, Peter |
author_sort | Anjorin, Aderike |
collection | PubMed |
description | SLE is a complex autoimmune disease with genetic and clinical differences between patients that appear to reside along ancestral lines. Over the last 20 years, a preponderance of evidence has shown that SLE is more common and severe in minority populations, particularly in African ancestry (AA) women. However, in clinical trials for new therapies of SLE, AA is often under-represented. Without enrolling sufficient AA participants, it is difficult to ascertain the safety and efficacy of new potential therapies among individuals with SLE of different ancestries. Although enrolling minority populations in clinical trials has been a significant challenge for many reasons, the various stakeholders involved in clinical research could act within their own realms to develop new paradigms and policies to bolster the inclusion of AA in the development of new therapies. |
format | Online Article Text |
id | pubmed-6307590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-63075902019-01-04 Engaging African ancestry participants in SLE clinical trials Anjorin, Aderike Lipsky, Peter Lupus Sci Med Review SLE is a complex autoimmune disease with genetic and clinical differences between patients that appear to reside along ancestral lines. Over the last 20 years, a preponderance of evidence has shown that SLE is more common and severe in minority populations, particularly in African ancestry (AA) women. However, in clinical trials for new therapies of SLE, AA is often under-represented. Without enrolling sufficient AA participants, it is difficult to ascertain the safety and efficacy of new potential therapies among individuals with SLE of different ancestries. Although enrolling minority populations in clinical trials has been a significant challenge for many reasons, the various stakeholders involved in clinical research could act within their own realms to develop new paradigms and policies to bolster the inclusion of AA in the development of new therapies. BMJ Publishing Group 2018-12-11 /pmc/articles/PMC6307590/ /pubmed/30613420 http://dx.doi.org/10.1136/lupus-2018-000297 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Review Anjorin, Aderike Lipsky, Peter Engaging African ancestry participants in SLE clinical trials |
title | Engaging African ancestry participants in SLE clinical trials |
title_full | Engaging African ancestry participants in SLE clinical trials |
title_fullStr | Engaging African ancestry participants in SLE clinical trials |
title_full_unstemmed | Engaging African ancestry participants in SLE clinical trials |
title_short | Engaging African ancestry participants in SLE clinical trials |
title_sort | engaging african ancestry participants in sle clinical trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307590/ https://www.ncbi.nlm.nih.gov/pubmed/30613420 http://dx.doi.org/10.1136/lupus-2018-000297 |
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