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Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol

INTRODUCTION: Total knee arthroplasty is a highly effective treatment for end-stage knee osteoarthritis, and it is usually performed under spinal or general anaesthesia with or without a surgical tourniquet. Some debate about the preferred mode of anaesthesia regarding patient outcomes remains. The...

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Autores principales: Rantasalo, Mikko Tuomas, Palanne, Riku, Juutilainen, Katarina, Kairaluoma, Pekka, Linko, Rita, Reponen, Elina, Helkamaa, Teemu, Vakkuri, Anne, Olkkola, Klaus T, Madanat, Rami, Skants, Noora Kati Annukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307602/
https://www.ncbi.nlm.nih.gov/pubmed/30580277
http://dx.doi.org/10.1136/bmjopen-2018-025546
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author Rantasalo, Mikko Tuomas
Palanne, Riku
Juutilainen, Katarina
Kairaluoma, Pekka
Linko, Rita
Reponen, Elina
Helkamaa, Teemu
Vakkuri, Anne
Olkkola, Klaus T
Madanat, Rami
Skants, Noora Kati Annukka
author_facet Rantasalo, Mikko Tuomas
Palanne, Riku
Juutilainen, Katarina
Kairaluoma, Pekka
Linko, Rita
Reponen, Elina
Helkamaa, Teemu
Vakkuri, Anne
Olkkola, Klaus T
Madanat, Rami
Skants, Noora Kati Annukka
author_sort Rantasalo, Mikko Tuomas
collection PubMed
description INTRODUCTION: Total knee arthroplasty is a highly effective treatment for end-stage knee osteoarthritis, and it is usually performed under spinal or general anaesthesia with or without a surgical tourniquet. Some debate about the preferred mode of anaesthesia regarding patient outcomes remains. The aim of this study, which compares general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty, is to determine the optimal type of anaesthesia regimen and assess the effect of a tourniquet on the patient’s recovery following total knee arthroplasty. METHODS AND ANALYSIS: This study is a randomised, controlled, parallel-group, four-arm study comparing spinal and general anaesthesia with and without a tourniquet in 400 patients undergoing fast-track total knee arthroplasty, with a 12-month follow-up. The primary outcome is cumulative intravenous oxycodone consumption by patient-controlled analgesia during the first 24 postoperative hours. Secondary outcomes include postoperative nausea and vomiting, the length of hospital stay, the duration of the surgery, blood loss, demand for surgical unit resources, complications, readmissions, postoperative knee function, range of motion, health-related quality of life, prolonged pain and mortality. ETHICS AND DISSEMINATION: This study’s protocol is in accordance with the declaration of Helsinki. The results of this study will be disseminated in international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03364088; Pre-results.
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spelling pubmed-63076022019-01-08 Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol Rantasalo, Mikko Tuomas Palanne, Riku Juutilainen, Katarina Kairaluoma, Pekka Linko, Rita Reponen, Elina Helkamaa, Teemu Vakkuri, Anne Olkkola, Klaus T Madanat, Rami Skants, Noora Kati Annukka BMJ Open Anaesthesia INTRODUCTION: Total knee arthroplasty is a highly effective treatment for end-stage knee osteoarthritis, and it is usually performed under spinal or general anaesthesia with or without a surgical tourniquet. Some debate about the preferred mode of anaesthesia regarding patient outcomes remains. The aim of this study, which compares general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty, is to determine the optimal type of anaesthesia regimen and assess the effect of a tourniquet on the patient’s recovery following total knee arthroplasty. METHODS AND ANALYSIS: This study is a randomised, controlled, parallel-group, four-arm study comparing spinal and general anaesthesia with and without a tourniquet in 400 patients undergoing fast-track total knee arthroplasty, with a 12-month follow-up. The primary outcome is cumulative intravenous oxycodone consumption by patient-controlled analgesia during the first 24 postoperative hours. Secondary outcomes include postoperative nausea and vomiting, the length of hospital stay, the duration of the surgery, blood loss, demand for surgical unit resources, complications, readmissions, postoperative knee function, range of motion, health-related quality of life, prolonged pain and mortality. ETHICS AND DISSEMINATION: This study’s protocol is in accordance with the declaration of Helsinki. The results of this study will be disseminated in international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03364088; Pre-results. BMJ Publishing Group 2018-12-22 /pmc/articles/PMC6307602/ /pubmed/30580277 http://dx.doi.org/10.1136/bmjopen-2018-025546 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Anaesthesia
Rantasalo, Mikko Tuomas
Palanne, Riku
Juutilainen, Katarina
Kairaluoma, Pekka
Linko, Rita
Reponen, Elina
Helkamaa, Teemu
Vakkuri, Anne
Olkkola, Klaus T
Madanat, Rami
Skants, Noora Kati Annukka
Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title_full Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title_fullStr Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title_full_unstemmed Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title_short Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
title_sort randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol
topic Anaesthesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307602/
https://www.ncbi.nlm.nih.gov/pubmed/30580277
http://dx.doi.org/10.1136/bmjopen-2018-025546
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