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Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease

OBJECTIVE: Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied....

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Autores principales: Minamisawa, Masatoshi, Koyama, Jun, Kozuka, Ayako, Miura, Takashi, Saigusa, Tatsuya, Ebisawa, Soichiro, Motoki, Hirohiko, Okada, Ayako, Ikeda, Uichi, Kuwahara, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307609/
https://www.ncbi.nlm.nih.gov/pubmed/30613412
http://dx.doi.org/10.1136/openhrt-2018-000896
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author Minamisawa, Masatoshi
Koyama, Jun
Kozuka, Ayako
Miura, Takashi
Saigusa, Tatsuya
Ebisawa, Soichiro
Motoki, Hirohiko
Okada, Ayako
Ikeda, Uichi
Kuwahara, Koichiro
author_facet Minamisawa, Masatoshi
Koyama, Jun
Kozuka, Ayako
Miura, Takashi
Saigusa, Tatsuya
Ebisawa, Soichiro
Motoki, Hirohiko
Okada, Ayako
Ikeda, Uichi
Kuwahara, Koichiro
author_sort Minamisawa, Masatoshi
collection PubMed
description OBJECTIVE: Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied. The aims of this study were to investigate whether left ventricular (LV) ESL duration could identify patients with CAD, and to examine the relationship between FFR and LV ESL duration. METHODS: In this single-centre, cross-sectional, prospective study of 75 patients with suspected or known CAD, we performed two-dimensional speckle tracking echocardiography at rest on the day before coronary angiography or percutaneous coronary intervention. Apical 3 views were used to examine ESL duration, defined as time from onset of the Q wave to maximum myocardial systolic lengthening. RESULTS: Thirty-five patients had non-significant stenosis. Forty patients with CAD underwent FFR testing: 17 had an FFR≥0.8 and 23 had an FFR<0.8. Global ESL duration was 20.9±22.2 ms in patients with non-significant stenosis, 36.4±23.2 ms in patients with FFR≥0.8 and 39.6±29.5 ms in patients with FFR<0.8 (p=0.020). However, global and regional ESL durations were not significantly correlated with FFR and demonstrated poor reproducibility. CONCLUSION: Although myocardial ESL duration was significantly prolonged in patients with CAD compared with patients without CAD, ESL at rest showed poor reproducibility, and this new parameter did not predict FFR in patients with suspected CAD.
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spelling pubmed-63076092019-01-04 Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease Minamisawa, Masatoshi Koyama, Jun Kozuka, Ayako Miura, Takashi Saigusa, Tatsuya Ebisawa, Soichiro Motoki, Hirohiko Okada, Ayako Ikeda, Uichi Kuwahara, Koichiro Open Heart Coronary Artery Disease OBJECTIVE: Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied. The aims of this study were to investigate whether left ventricular (LV) ESL duration could identify patients with CAD, and to examine the relationship between FFR and LV ESL duration. METHODS: In this single-centre, cross-sectional, prospective study of 75 patients with suspected or known CAD, we performed two-dimensional speckle tracking echocardiography at rest on the day before coronary angiography or percutaneous coronary intervention. Apical 3 views were used to examine ESL duration, defined as time from onset of the Q wave to maximum myocardial systolic lengthening. RESULTS: Thirty-five patients had non-significant stenosis. Forty patients with CAD underwent FFR testing: 17 had an FFR≥0.8 and 23 had an FFR<0.8. Global ESL duration was 20.9±22.2 ms in patients with non-significant stenosis, 36.4±23.2 ms in patients with FFR≥0.8 and 39.6±29.5 ms in patients with FFR<0.8 (p=0.020). However, global and regional ESL durations were not significantly correlated with FFR and demonstrated poor reproducibility. CONCLUSION: Although myocardial ESL duration was significantly prolonged in patients with CAD compared with patients without CAD, ESL at rest showed poor reproducibility, and this new parameter did not predict FFR in patients with suspected CAD. BMJ Publishing Group 2018-12-04 /pmc/articles/PMC6307609/ /pubmed/30613412 http://dx.doi.org/10.1136/openhrt-2018-000896 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Coronary Artery Disease
Minamisawa, Masatoshi
Koyama, Jun
Kozuka, Ayako
Miura, Takashi
Saigusa, Tatsuya
Ebisawa, Soichiro
Motoki, Hirohiko
Okada, Ayako
Ikeda, Uichi
Kuwahara, Koichiro
Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title_full Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title_fullStr Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title_full_unstemmed Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title_short Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
title_sort duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
topic Coronary Artery Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307609/
https://www.ncbi.nlm.nih.gov/pubmed/30613412
http://dx.doi.org/10.1136/openhrt-2018-000896
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