NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2

Histone lysine methylation plays an important role in the regulation of ventricular remodelling. NSD2 is involved in many types of tumours through enhancing H3K36me2 expression. However, the role of NSD2 in the regulation of histone lysine methylation during ventricular remodelling remains unclear....

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Autores principales: Zhou, Xue‐liang, Zhu, Rong‐rong, Wu, Xia, Xu, Hua, Li, Yun‐yun, Xu, Qi‐rong, Liu, Sheng, Huang, Huang, Xu, Xinping, Wan, Li, Wu, Qi‐cai, Liu, Ji‐chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307761/
https://www.ncbi.nlm.nih.gov/pubmed/30334333
http://dx.doi.org/10.1111/jcmm.13961
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author Zhou, Xue‐liang
Zhu, Rong‐rong
Wu, Xia
Xu, Hua
Li, Yun‐yun
Xu, Qi‐rong
Liu, Sheng
Huang, Huang
Xu, Xinping
Wan, Li
Wu, Qi‐cai
Liu, Ji‐chun
author_facet Zhou, Xue‐liang
Zhu, Rong‐rong
Wu, Xia
Xu, Hua
Li, Yun‐yun
Xu, Qi‐rong
Liu, Sheng
Huang, Huang
Xu, Xinping
Wan, Li
Wu, Qi‐cai
Liu, Ji‐chun
author_sort Zhou, Xue‐liang
collection PubMed
description Histone lysine methylation plays an important role in the regulation of ventricular remodelling. NSD2 is involved in many types of tumours through enhancing H3K36me2 expression. However, the role of NSD2 in the regulation of histone lysine methylation during ventricular remodelling remains unclear. In this study, we established cardiac hypertrophy model in C57BL/6 mice by transverse aortic constriction and found that histone lysine methylation participated in ventricular remodelling regulation via the up‐regulation of H3K27me2 and H3K36me2 expression. In addition, we constructed transgenic C57BL/6 mice with conditional knockout of NSD2 (NSD2(−/−)) in the myocardium. NSD2(−/−) C57BL/6 mice had milder ventricular remodelling and significantly improved cardiac function compared with wild‐type mice, and the expression of H3K36me2 but not H3K27me2 was down‐regulated. In conclusion, NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2.
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spelling pubmed-63077612019-01-04 NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2 Zhou, Xue‐liang Zhu, Rong‐rong Wu, Xia Xu, Hua Li, Yun‐yun Xu, Qi‐rong Liu, Sheng Huang, Huang Xu, Xinping Wan, Li Wu, Qi‐cai Liu, Ji‐chun J Cell Mol Med Original Articles Histone lysine methylation plays an important role in the regulation of ventricular remodelling. NSD2 is involved in many types of tumours through enhancing H3K36me2 expression. However, the role of NSD2 in the regulation of histone lysine methylation during ventricular remodelling remains unclear. In this study, we established cardiac hypertrophy model in C57BL/6 mice by transverse aortic constriction and found that histone lysine methylation participated in ventricular remodelling regulation via the up‐regulation of H3K27me2 and H3K36me2 expression. In addition, we constructed transgenic C57BL/6 mice with conditional knockout of NSD2 (NSD2(−/−)) in the myocardium. NSD2(−/−) C57BL/6 mice had milder ventricular remodelling and significantly improved cardiac function compared with wild‐type mice, and the expression of H3K36me2 but not H3K27me2 was down‐regulated. In conclusion, NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2. John Wiley and Sons Inc. 2018-10-18 2019-01 /pmc/articles/PMC6307761/ /pubmed/30334333 http://dx.doi.org/10.1111/jcmm.13961 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhou, Xue‐liang
Zhu, Rong‐rong
Wu, Xia
Xu, Hua
Li, Yun‐yun
Xu, Qi‐rong
Liu, Sheng
Huang, Huang
Xu, Xinping
Wan, Li
Wu, Qi‐cai
Liu, Ji‐chun
NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title_full NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title_fullStr NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title_full_unstemmed NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title_short NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
title_sort nsd2 promotes ventricular remodelling mediated by the regulation of h3k36me2
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307761/
https://www.ncbi.nlm.nih.gov/pubmed/30334333
http://dx.doi.org/10.1111/jcmm.13961
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