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MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway
Although the non‐small cell lung cancer (NSCLC) is one of the most malignant tumours worldwide, the mechanisms controlling NSCLC tumourigenesis remain unclear. Here, we find that the expression of miR‐520b is up‐regulated in NSCLC samples. Further studies have revealed that miR‐520b promotes the pro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307803/ https://www.ncbi.nlm.nih.gov/pubmed/30407707 http://dx.doi.org/10.1111/jcmm.13909 |
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author | Liu, Xiaoming Liu, Jichun Zhang, Xuekang Tong, Yuben Gan, Xin |
author_facet | Liu, Xiaoming Liu, Jichun Zhang, Xuekang Tong, Yuben Gan, Xin |
author_sort | Liu, Xiaoming |
collection | PubMed |
description | Although the non‐small cell lung cancer (NSCLC) is one of the most malignant tumours worldwide, the mechanisms controlling NSCLC tumourigenesis remain unclear. Here, we find that the expression of miR‐520b is up‐regulated in NSCLC samples. Further studies have revealed that miR‐520b promotes the proliferation and metastasis of NSCLC cells. In addition, miR‐520b activates Hedgehog (Hh) pathway. Inhibitor of Hh pathway could relieve the oncogenic effect of miR‐520b upon NSCLC cells. Mechanistically, we demonstrate that miR‐520b directly targets SPOP 3′‐UTR and decreases SPOP expression, culminating in GLI2/3 stabilization and Hh pathway hyperactivation. Collectively, our findings unveil that miR‐520b promotes NSCLC tumourigenesis through SPOP‐GLI2/3 axis and provide miR‐520b as a potential diagnostic biomarker and therapeutic target for NSCLC. |
format | Online Article Text |
id | pubmed-6307803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63078032019-01-04 MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway Liu, Xiaoming Liu, Jichun Zhang, Xuekang Tong, Yuben Gan, Xin J Cell Mol Med Original Articles Although the non‐small cell lung cancer (NSCLC) is one of the most malignant tumours worldwide, the mechanisms controlling NSCLC tumourigenesis remain unclear. Here, we find that the expression of miR‐520b is up‐regulated in NSCLC samples. Further studies have revealed that miR‐520b promotes the proliferation and metastasis of NSCLC cells. In addition, miR‐520b activates Hedgehog (Hh) pathway. Inhibitor of Hh pathway could relieve the oncogenic effect of miR‐520b upon NSCLC cells. Mechanistically, we demonstrate that miR‐520b directly targets SPOP 3′‐UTR and decreases SPOP expression, culminating in GLI2/3 stabilization and Hh pathway hyperactivation. Collectively, our findings unveil that miR‐520b promotes NSCLC tumourigenesis through SPOP‐GLI2/3 axis and provide miR‐520b as a potential diagnostic biomarker and therapeutic target for NSCLC. John Wiley and Sons Inc. 2018-11-08 2019-01 /pmc/articles/PMC6307803/ /pubmed/30407707 http://dx.doi.org/10.1111/jcmm.13909 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Xiaoming Liu, Jichun Zhang, Xuekang Tong, Yuben Gan, Xin MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title | MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title_full | MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title_fullStr | MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title_full_unstemmed | MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title_short | MiR‐520b promotes the progression of non‐small cell lung cancer through activating Hedgehog pathway |
title_sort | mir‐520b promotes the progression of non‐small cell lung cancer through activating hedgehog pathway |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307803/ https://www.ncbi.nlm.nih.gov/pubmed/30407707 http://dx.doi.org/10.1111/jcmm.13909 |
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