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CUDC‐907 blocks multiple pro‐survival signals and abrogates microenvironment protection in CLL

CUDC‐907, a dual PI3K/HDAC inhibitor, has been proposed to have therapeutic potential in hematopoietic malignancies. However, the molecular mechanisms of its effects in chronic lymphocytic leukaemia (CLL) remain elusive. We show that CLL cells are sensitive to CUDC‐907, even under conditions similar...

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Detalles Bibliográficos
Autores principales:	Chen, Yixiang, Peubez, Chloé, Smith, Victoria, Xiong, Shiqiu, Kocsis‐Fodor, Gabriella, Kennedy, Ben, Wagner, Simon, Balotis, Constantine, Jayne, Sandrine, Dyer, Martin J. S., Macip, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307843/ https://www.ncbi.nlm.nih.gov/pubmed/30353642 http://dx.doi.org/10.1111/jcmm.13935

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