Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin

Conditional deletion of RBP-J, the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence of contributing factors such as mouse strain, cell of origin and Cre recombinase copy number are unknow...

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Detalles Bibliográficos
Autores principales: Belyea, Brian Chipman, Xu, Fang, Sequeira-Lopez, Maria Luisa Soledad, Gomez, Roberto Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307899/
https://www.ncbi.nlm.nih.gov/pubmed/30467111
http://dx.doi.org/10.1242/dmm.036731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307899/
https://www.ncbi.nlm.nih.gov/pubmed/30467111
http://dx.doi.org/10.1242/dmm.036731

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