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Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Antibiotic resistance is a major public health threat worldwide. In particular, about 80% of cystic fibrosis patients have chronic Pseudomonas aeruginosa (PA) lung infection resistant to many current antibiotics. We are therefore developing a novel class of antivirulence agents, quorum sensing inhib...

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Detalles Bibliográficos
Autores principales:	Sou, Tomás, Kukavica-Ibrulj, Irena, Soukarieh, Fadi, Halliday, Nigel, Levesque, Roger C., Williams, Paul, Stocks, Michael, Cámara, Miguel, Friberg, Lena E., Bergström, Christel A.S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307981/ https://www.ncbi.nlm.nih.gov/pubmed/30257195 http://dx.doi.org/10.1016/j.xphs.2018.09.017

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