Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key enzyme in tryptophan metabolism and plays an important role in tumor cell immunosuppression and angiogenesis. The molecular mechanisms of IDO1 and epithelial-mesenchymal transition (EMT) have not been elucidated or studied in bladder cancer. Therefore, t...

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Detalles Bibliográficos
Autores principales: Zhang, Wentao, Zhang, Junfeng, Zhang, Ziwei, Guo, Yadong, Wu, Yuan, Wang, Ruiliang, Wang, Longsheng, Mao, Shiyu, Yao, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307990/
https://www.ncbi.nlm.nih.gov/pubmed/30594037
http://dx.doi.org/10.1016/j.tranon.2018.11.012

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