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Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high exp...

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Autores principales: Feng, Yangbo, Xiong, Yanlu, Qiao, Tianyun, Li, Xiaofei, Jia, Lintao, Han, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308051/
https://www.ncbi.nlm.nih.gov/pubmed/30403008
http://dx.doi.org/10.1002/cam4.1820
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author Feng, Yangbo
Xiong, Yanlu
Qiao, Tianyun
Li, Xiaofei
Jia, Lintao
Han, Yong
author_facet Feng, Yangbo
Xiong, Yanlu
Qiao, Tianyun
Li, Xiaofei
Jia, Lintao
Han, Yong
author_sort Feng, Yangbo
collection PubMed
description Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research. First, we gave an introduction of structure, location, and basic function of LDHA. Following, we discussed the transcription and activation mode of LDHA. Further, we focused on the function of LDHA in cancer bio‐characteristics. Later, we discussed the clinical practice of LDHA in cancer prevention and treatment. What we discussed gives a precise insight into LDHA especially in cancer research, which will contribute to exploring cancer pathogenesis and its handling measures.
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spelling pubmed-63080512019-01-03 Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy Feng, Yangbo Xiong, Yanlu Qiao, Tianyun Li, Xiaofei Jia, Lintao Han, Yong Cancer Med Cancer Biology Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research. First, we gave an introduction of structure, location, and basic function of LDHA. Following, we discussed the transcription and activation mode of LDHA. Further, we focused on the function of LDHA in cancer bio‐characteristics. Later, we discussed the clinical practice of LDHA in cancer prevention and treatment. What we discussed gives a precise insight into LDHA especially in cancer research, which will contribute to exploring cancer pathogenesis and its handling measures. John Wiley and Sons Inc. 2018-11-06 /pmc/articles/PMC6308051/ /pubmed/30403008 http://dx.doi.org/10.1002/cam4.1820 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Feng, Yangbo
Xiong, Yanlu
Qiao, Tianyun
Li, Xiaofei
Jia, Lintao
Han, Yong
Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title_full Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title_fullStr Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title_full_unstemmed Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title_short Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
title_sort lactate dehydrogenase a: a key player in carcinogenesis and potential target in cancer therapy
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308051/
https://www.ncbi.nlm.nih.gov/pubmed/30403008
http://dx.doi.org/10.1002/cam4.1820
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