Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

BACKGROUND: Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors. MATERIALS AND METHODS: A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC‐TC group and BC‐alone group. RESULTS: In tot...

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Detalles Bibliográficos
Autores principales: Huang, Nai‐si, Chen, Xing‐xing, Wei, Wen‐jun, Mo, Miao, Chen, Jia‐ying, Ma, Ben, Yang, Shu‐wen, Xu, Wei‐bo, Wu, Jiong, Ji, Qing‐hai, Guo, Xiao‐mao, Liu, Guang‐yu, Shao, Zhi‐min, Wang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Prevention
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308067/
https://www.ncbi.nlm.nih.gov/pubmed/30480382
http://dx.doi.org/10.1002/cam4.1856
Descripción
Sumario:BACKGROUND: Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors. MATERIALS AND METHODS: A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC‐TC group and BC‐alone group. RESULTS: In total, 13 978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio = 1.457, P = 0.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC‐TC (P = 0.016). Synchronous BC‐TC (risk ratio = 5.597, P = 0.018) was an independent prognostic factor for inferior RFS. CONCLUSIONS: We observed high co‐occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC‐TC.

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