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Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset

BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer us...

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Autores principales: Nakagawa, Nobuhiko, Kanda, Mitsuro, Ito, Seiji, Mochizuki, Yoshinari, Teramoto, Hitoshi, Ishigure, Kiyoshi, Murai, Toshifumi, Asada, Takahiro, Ishiyama, Akiharu, Matsushita, Hidenobu, Tanaka, Chie, Kobayashi, Daisuke, Fujiwara, Michitaka, Murotani, Kenta, Kodera, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308072/
https://www.ncbi.nlm.nih.gov/pubmed/30411544
http://dx.doi.org/10.1002/cam4.1868
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author Nakagawa, Nobuhiko
Kanda, Mitsuro
Ito, Seiji
Mochizuki, Yoshinari
Teramoto, Hitoshi
Ishigure, Kiyoshi
Murai, Toshifumi
Asada, Takahiro
Ishiyama, Akiharu
Matsushita, Hidenobu
Tanaka, Chie
Kobayashi, Daisuke
Fujiwara, Michitaka
Murotani, Kenta
Kodera, Yasuhiro
author_facet Nakagawa, Nobuhiko
Kanda, Mitsuro
Ito, Seiji
Mochizuki, Yoshinari
Teramoto, Hitoshi
Ishigure, Kiyoshi
Murai, Toshifumi
Asada, Takahiro
Ishiyama, Akiharu
Matsushita, Hidenobu
Tanaka, Chie
Kobayashi, Daisuke
Fujiwara, Michitaka
Murotani, Kenta
Kodera, Yasuhiro
author_sort Nakagawa, Nobuhiko
collection PubMed
description BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching. RESULTS: After propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44). CONCLUSIONS: INF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer.
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spelling pubmed-63080722019-01-03 Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset Nakagawa, Nobuhiko Kanda, Mitsuro Ito, Seiji Mochizuki, Yoshinari Teramoto, Hitoshi Ishigure, Kiyoshi Murai, Toshifumi Asada, Takahiro Ishiyama, Akiharu Matsushita, Hidenobu Tanaka, Chie Kobayashi, Daisuke Fujiwara, Michitaka Murotani, Kenta Kodera, Yasuhiro Cancer Med Clinical Cancer Research BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching. RESULTS: After propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44). CONCLUSIONS: INF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer. John Wiley and Sons Inc. 2018-11-08 /pmc/articles/PMC6308072/ /pubmed/30411544 http://dx.doi.org/10.1002/cam4.1868 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Nakagawa, Nobuhiko
Kanda, Mitsuro
Ito, Seiji
Mochizuki, Yoshinari
Teramoto, Hitoshi
Ishigure, Kiyoshi
Murai, Toshifumi
Asada, Takahiro
Ishiyama, Akiharu
Matsushita, Hidenobu
Tanaka, Chie
Kobayashi, Daisuke
Fujiwara, Michitaka
Murotani, Kenta
Kodera, Yasuhiro
Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title_full Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title_fullStr Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title_full_unstemmed Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title_short Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
title_sort pathological tumor infiltrative pattern and sites of initial recurrence in stage ii/iii gastric cancer: propensity score matching analysis of a multi‐institutional dataset
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308072/
https://www.ncbi.nlm.nih.gov/pubmed/30411544
http://dx.doi.org/10.1002/cam4.1868
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