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Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer us...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308072/ https://www.ncbi.nlm.nih.gov/pubmed/30411544 http://dx.doi.org/10.1002/cam4.1868 |
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author | Nakagawa, Nobuhiko Kanda, Mitsuro Ito, Seiji Mochizuki, Yoshinari Teramoto, Hitoshi Ishigure, Kiyoshi Murai, Toshifumi Asada, Takahiro Ishiyama, Akiharu Matsushita, Hidenobu Tanaka, Chie Kobayashi, Daisuke Fujiwara, Michitaka Murotani, Kenta Kodera, Yasuhiro |
author_facet | Nakagawa, Nobuhiko Kanda, Mitsuro Ito, Seiji Mochizuki, Yoshinari Teramoto, Hitoshi Ishigure, Kiyoshi Murai, Toshifumi Asada, Takahiro Ishiyama, Akiharu Matsushita, Hidenobu Tanaka, Chie Kobayashi, Daisuke Fujiwara, Michitaka Murotani, Kenta Kodera, Yasuhiro |
author_sort | Nakagawa, Nobuhiko |
collection | PubMed |
description | BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching. RESULTS: After propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44). CONCLUSIONS: INF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer. |
format | Online Article Text |
id | pubmed-6308072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63080722019-01-03 Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset Nakagawa, Nobuhiko Kanda, Mitsuro Ito, Seiji Mochizuki, Yoshinari Teramoto, Hitoshi Ishigure, Kiyoshi Murai, Toshifumi Asada, Takahiro Ishiyama, Akiharu Matsushita, Hidenobu Tanaka, Chie Kobayashi, Daisuke Fujiwara, Michitaka Murotani, Kenta Kodera, Yasuhiro Cancer Med Clinical Cancer Research BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching. RESULTS: After propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44). CONCLUSIONS: INF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer. John Wiley and Sons Inc. 2018-11-08 /pmc/articles/PMC6308072/ /pubmed/30411544 http://dx.doi.org/10.1002/cam4.1868 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Nakagawa, Nobuhiko Kanda, Mitsuro Ito, Seiji Mochizuki, Yoshinari Teramoto, Hitoshi Ishigure, Kiyoshi Murai, Toshifumi Asada, Takahiro Ishiyama, Akiharu Matsushita, Hidenobu Tanaka, Chie Kobayashi, Daisuke Fujiwara, Michitaka Murotani, Kenta Kodera, Yasuhiro Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title | Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title_full | Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title_fullStr | Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title_full_unstemmed | Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title_short | Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset |
title_sort | pathological tumor infiltrative pattern and sites of initial recurrence in stage ii/iii gastric cancer: propensity score matching analysis of a multi‐institutional dataset |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308072/ https://www.ncbi.nlm.nih.gov/pubmed/30411544 http://dx.doi.org/10.1002/cam4.1868 |
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